Publications by authors named "Linda Sanderman"

High-grade serous carcinoma of the ovary is a deadly gynecological cancer with poor long-term survival. Dysregulation of microRNAs has been shown to contribute to the formation of cancer stem cells (CSCs), an important part of oncogenesis and tumor progression. The family of microRNAs has previously been shown to regulate stemness and has tumor suppressive actions in a variety of cancers, including ovarian.

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Article Synopsis
  • Patient-derived samples offer a more reliable model for studying high-grade serous ovarian cancer (HGSOC) compared to traditional cell line models, as they accurately reflect the in vivo characteristics of the disease.
  • Researchers characterized patient-derived xenograft (PDX) models, discovering that samples exhibited a hybrid of epithelial and mesenchymal traits, impacting their self-renewal and tumorigenicity.
  • A notable finding was the inverse relationship between let-7 microRNA and stemness, suggesting that lower let-7 levels correlate with greater tumorigenic potential and sensitivity to chemotherapy, while also indicating that stemness and invasiveness can be dissociated in HGSOC cells.
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