Publications by authors named "Linda Pummer"
Article Synopsis
- Viral respiratory infections pose significant risks to young children, especially premature infants, leading to high hospitalization rates.
- Researchers studied nasal epithelial cells to explore age-related immune responses to viruses, using a specialized cell culture method to assess their reactions to influenza A and RSV.
- The findings revealed key differences in the immune mechanisms of neonatal versus adult nasal cells, highlighting specific pathways and networks that are important for understanding how age affects responses to respiratory infections.
Article Synopsis
- This study investigated the impact of scheduled lung recruitment maneuvers (LRMs) versus only when needed on extremely preterm infants undergoing high-frequency oscillatory ventilation (HFOV).* -
- In a randomized controlled trial with 30 infants (15 in each group), results showed no significant difference in the cumulative oxygen saturation index (OSI) or frequency of LRMs between both groups over a week.* -
- The findings suggest that performing LRMs regularly doesn't enhance lung volume compared to clinically indicated maneuvers, with most benefit seen when oxygen levels (FiO2) are high.*
Plasmacytoid dendritic cells (pDCs) are key players in the antiviral immune response and type III IFNs such as IL-29 appear to play a pivotal role in pDC function. Pronounced susceptibility to viral infections in neonates is partly resulting from diminished antiviral immune mechanisms. Accordingly, the aim of the present study was to investigate the impact of IL-29 in the altered immune response of neonatal pDCs.
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