Safety and Efficacy of Surgical and Percutaneous Cardiac Interventions for Adults With Down Syndrome.

Objective: To assess risks and benefits of cardiac intervention in adults with Down syndrome (DS).

Patients And Methods: A retrospective review was conducted using data from a study we published in 2010. Patients aged 18 years or older with DS who underwent cardiac operation or percutaneous intervention from February 2009 through April 2022 (new cohort) were compared with patients in the previous study (January 1969 through November 2007; remote cohort) at Mayo Clinic.

Assessing the effects of sunlight and water on asphalt binder and pavement leachability related to the environment.

Extensive global research conducted over 30 years explores asphalt leachability and stormwater runoff. Asphalt's widespread usage in construction materials underscores the importance of understanding its environmental consequences. This study aims to assess the influence of sunlight exposure on water quality, particularly regarding the release of hazardous organic compounds such as polycyclic aromatic compounds.

Assessing cancer hazards of bitumen emissions - a case study for complex petroleum substances.

When assessing cancer hazard and risk associated with a complex petroleum substance, like bitumen emissions, there are often conflicting results related to human, animal and mechanistic studies. Validation of the complex composition to assure that it matches real-world exposures and control of confounders are pivotal factors in study design to allow the necessary read-across during assessments. Several key studies on bitumen emissions in two-year dermal cancer assays reported variable outcomes ranging from high cancer incidence to no cancer incidence.

Airborne Exposures to Polycyclic Aromatic Compounds Among Workers in Asphalt Roofing Manufacturing Facilities.

We studied exposure of 151 workers to polycyclic aromatic compounds and asphalt emissions during the manufacturing of asphalt roofing products-including 64 workers from 10 asphalt plants producing oxidized, straight-run, cutback, and wax- or polymer-modified asphalts, and 87 workers from 11 roofing plants producing asphalt shingles and granulated roll roofing. The facilities were located throughout the United States and used asphalt from many refiners and crude oils. This article helps fill a gap in exposure data for asphalt roofing manufacturing workers by using a fluorescence technique that targets biologically active 4-6 ring polycyclic aromatic compounds and is strongly correlated with carcinogenic activity in animal studies.

Effect of Temperature and Process on Quantity and Composition of Laboratory-generated Bitumen Emissions.

In this study we investigated the impact of temperature on emissions as related to various bitumen applications and processes used in commercial products. Bitumen emissions are very complex and can be influenced in quantity and composition by differences in crude source, refining processes, application temperature, and work practices. This study provided a controlled laboratory environment to study five bitumen test materials from three European refineries; three paving grade, one used for primarily roofing and some paving applications, and one oxidized industrial specialty bitumen.

Personal breathing zone exposures among hot-mix asphalt paving workers; preliminary analysis for trends and analysis of work practices that resulted in the highest exposure concentrations.

An exposure assessment of hot-mix asphalt (HMA) paving workers was conducted to determine which of four exposure scenarios impacted worker exposure and dose. Goals of this report are to present the personal-breathing zone (PBZ) data, discuss the impact of substituting the releasing/cleaning agent, and discuss work practices that resulted in the highest exposure concentration for each analyte. One-hundred-seven PBZ samples were collected from HMA paving workers on days when diesel oil was used as a releasing/cleaning agent.

Using urinary biomarkers of polycyclic aromatic compound exposure to guide exposure-reduction strategies among asphalt paving workers.

Introduction: Paving workers are exposed to polycyclic aromatic compounds (PACs) while working with hot-mix asphalt (HMA). Further characterization of the source and route of these exposures is necessary to guide exposure-reduction strategies.

Methods: Personal air (n=144), hand-wash (n=144), and urine (n=480) samples were collected from 12 paving workers over 3 workdays during 4 workweeks.

Predictors of dermal exposures to polycyclic aromatic compounds among hot-mix asphalt paving workers.

Objectives: The primary objective of this study was to identify the source and work practices that affect dermal exposure to polycyclic aromatic compounds (PACs) among hot-mix asphalt (HMA) paving workers.

Methods: Four workers were recruited from each of three asphalt paving crews (12 workers) and were monitored for three consecutive days over 4 weeks for a total of 12 sampling days per worker (144 worker days). Two sampling weeks were conducted under standard conditions for dermal exposures.

Predictors of airborne exposures to polycyclic aromatic compounds and total organic matter among hot-mix asphalt paving workers and influence of work conditions and practices.

Objectives: We evaluated personal airborne exposures to polycyclic aromatic compounds (PACs) and total organic matter (TOM) among hot-mix asphalt (HMA) paving workers. The primary objectives of this study were to identify predictors of airborne PAC exposures, identify PAC exposure sources, and characterize how work practices may affect personal airborne exposure to PACs.

Methods: Four workers were recruited from each of three asphalt paving crews (12 workers) and were monitored for three consecutive days over 4 weeks for a total of 12 sampling days per worker (144 worker-days).

Effect of oxidation and extent of oxidation on biologically active PACs in asphalt products.

Recent studies have reported divergent results in rodent cancer assays using fume condensates from a variety of asphalt products. This paper presents results of a study investigating the role of oxidation, or extent of oxidation, on these findings. Five straight run asphalts, made from widely used crude oils, were used as inputs to both production scale and laboratory oxidation units and processed to a range of softening points used in common roofing products.

Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates.

Asphalt (bitumen) fume condensates collected from the headspace above paving and Type III built up roofing asphalt (BURA) tanks were evaluated in two-year dermal carcinogenicity assays in male C3H/HeNCrl mice. A third sample was generated from the BURA using a NIOSH laboratory generation method. Similar to earlier NIOSH studies, the BURA fume condensates were applied dermally in mineral oil twice per week; the paving sample was applied 7 days/week for a total weekly dose of 50 mg/wk in both studies.

Side-by-side comparison of field monitoring methods for hot bitumen emission exposures: the German IFA Method 6305, U.S. NIOSH Method 5042, and the Total Organic Matter Method.

Field studies were conducted at paving and roofing sites to compare the German Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) Fourier transform infrared spectroscopy method 6305 with the National Institute for Occupational Science and Health (NIOSH) benzene soluble fraction method 5042 plus total organic matter. Sampling using both methods was performed in multiple bitumen-related workplace environments. To provide comparable data all samplings were performed in parallel, and the analytical data were related to the same representative bitumen condensate standard.

Status of worker exposure to asphalt paving fumes with the use of engineering controls.

Since 1996, industry, labor, and government have partnered to minimize workers' exposure to asphalt fumes using engineering controls. The objective of this study was to determine the use after some years of experience and to benchmark the effectiveness of the engineering controls as compared to the current exposure limits. To accomplish this objective, the current highway class pavers equipped with controls to reduce asphalt fumes, occupational exposure levels, and ventilation flow rates were monitored, and a user acceptance survey was conducted.

Total versus inhalable sampler comparison study for the determination of asphalt fume exposures within the road paving industry.

Exposure to asphalt fumes has a threshold limit value (TLV of 0.5 mg m(-3) (benzene extractable inhalable particulate) as recommended by the American Conference of Governmental Industrial Hygienists (ACGIH). This reflects a recent change (2000) whereby two variables are different from the previous recommendation.

Evaluation of worker exposure to asphalt roofing fumes: influence of work practices and materials.

A field study was conducted on 42 asphalt-roofing workers at 7 built-up roofing sites across the United States. Sixteen out of 42 samples show levels of exposure to asphalt fumes that exceed the current American Conference of Governmental Industrial Hygienists' (ACGIH)-recommended threshold limit value of 0.5 mg/m(3) as benzene extractable inhalable particulate.

Evaluation of worker exposure to asphalt paving fumes using traditional and nontraditional techniques.

Forty-five workers at 11 paving sites across the United States were evaluated for exposure to paving asphalt (bitumen) fumes. Traditional measures of exposure such as total particulate matter (TPM) and benzene soluble matter (BSM) were monitored. In addition, total organic matter (TOM), which includes both the BSM residue and the more volatile components that pass through the filter and are collected on sorption material, was quantified and further characterized using a gas chromatography technique and a recently developed fluorescence test.