Publications by authors named "Linda Nyame"
Article Synopsis
- The study investigates the link between long-term exposure to particulate matter (PM) and frailty in middle-aged and older Chinese adults, focusing on the exposure-response relationship.
- Data were gathered from air quality monitoring and the China Health and Retirement Longitudinal Study, using a frailty index based on 39 indicators and multilevel regression models for analysis.
- Findings revealed that long-term exposure to PM2.5, PM10, and PMc significantly increased the risk of pre-frailty and frailty, indicating a linear relationship for PM2.5 and a nonlinear relationship for PM10 and PMc, robust across multiple sensitivity analyses.
Characteristics and trends in adverse drug reactions in Ghana-evidence of spontaneous reports, 2005-2021.
Naunyn Schmiedebergs Arch Pharmacol
July 2024
Article Synopsis
- The study analyzes adverse drug reactions (ADRs) reported in Ghana over 16 years, highlighting the significance of ADR monitoring for patient safety.
- A total of 6853 individual case safety reports were reviewed, revealing a significant increase in ADR rates from 2005 to 2019, particularly in males and with antiprotozoals as the most frequently associated medications.
- Despite a recent decline in ADR reports from 2019 to 2021, the findings emphasize the need for strategies to minimize medication-related risks in Ghana's healthcare system.*
Background: Adverse drug events (ADEs) represent challenges affecting Africa's healthcare systems owing to the increased healthcare expenditure and negative health outcomes of ADEs.
Objectives: We aimed to systematically review published studies on ADEs and synthesize the existing evidence of ADE prevalence in Africa.
Methods: Studies reporting on ADE occurrence in African settings and published from Jan 1, 2000 to Oct 1, 2023 were identified by searching PubMed, EBSCO, Science Direct, and Web of Science.
[This corrects the article on p. 531 in vol. 11, PMID: 32695060.
View Article and Find Full Text PDFAccurate prediction of functional outcomes after stroke would provide evidence for reasonable poststroke management. This study aimed to develop and validate a nomogram for individualized prediction of 1-year unfavorable outcomes in Chinese acute ischemic stroke (AIS) patients. We gathered AIS patients at the National Advanced Stroke Center of Nanjing First Hospital (China) between August 2014 and May 2017 within 12 h of symptom onset.
View Article and Find Full Text PDFIntroduction: Little is known about the relationship between smoking and clinical outcomes in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT). The outcomes could depend on different stroke subtypes. The aim of this study was to investigate whether smoking affected differently the outcomes in patients with different stroke subtypes who received MT.
View Article and Find Full Text PDFBackground And Purpose: Mechanical thrombectomy (MT) is a standard care for most acute ischemic stroke (AIS) patients. For AIS patients underwent MT, predicting the patients at high risk of unfavorable outcome and adjusting therapeutic strategies accordingly can greatly improve patient outcomes. We aimed to develop and validate a nomogram for individualized prediction of Chinese AIS patients underwent MT.
View Article and Find Full Text PDFThe clinical use of tirofiban for patients with acute ischemic stroke (AIS) who underwent mechanical thrombectomy (MT) remains controversial. We aimed to evaluate the safety and efficacy of tirofiban combined with MT in AIS patients. Patients with AIS who underwent MT from January 2014 to December 2018 were enrolled in three stroke units in China.
View Article and Find Full Text PDFArticle Synopsis
- Early prediction of unfavorable outcomes after ischemic stroke is crucial for effective clinical management, leading to the development of a nomogram that visually represents the risk based on individual patient factors.* -
- A study involving 499 Chinese patients identified key predictors for 6-month unfavorable outcomes, such as NIHSS score at admission, age, diabetes history, and creatinine levels, and created a predictive model using these factors.* -
- The resulting NADE nomogram demonstrated good predictive accuracy (AUC-ROC of 0.791) and was validated through statistical tests, making it a valuable tool for personalized outcome prediction after ischemic stroke.*
Background: Recently, the NIHSS STroke Scale score, Age, pre-stroke mRS score, onset-to-treatment Time (START nomogram) predicts 3-month functional outcome after intravenous thrombolysis in ischemic stroke patients. However, this model has not yet been an external validation. We aim to validate the performance of START nomogram.
View Article and Find Full Text PDFBackground: Accurate prognostication of unfavorable outcome made at the early onset of stroke is important to both the clinician and the patient management. This study was aimed to develop a nomogram based on the integration of parameters to predict the probability of 3-month unfavorable functional outcome in Chinese acute ischemic stroke patients.
Methods: We retrospectively collected patients who underwent acute ischemic stroke at Stroke Center of the Nanjing First Hospital (China) between May 2013 and May 2018.
Purpose: Some studies in the white population have shown that carriers of at least 1 loss-of-function allele in the gene that encodes the cytochrome P-450 2C19 isozyme (CYP2C19) have lower levels of the clopidogrel active metabolite (CAM) and a reduced antiplatelet effect of clopidogrel. However, data are limited regarding the association between CYP2C19 genetic variants and exposure to CAM and on the pharmacodynamic properties of CAM in the Chinese population. Data from the white population cannot be extrapolated to the Chinese population because of the marked interethnic differences in CYP2C19 variants.
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