Publications by authors named "Linda McKinnel"
Background: The Atlantic salmon (Salmo salar) immunoglobulin heavy chain (IgH) locus possesses two parallel IgH isoloci (IGH-A and IGH-B), that are related to the genomic duplication event in the family Salmonidae. These duplicated IgH loci in Atlantic salmon provide a unique opportunity to examine the mechanisms of genome diversity and genome evolution of the IgH loci in vertebrates. In this study, we defined the structure of these loci in Atlantic salmon, and sequenced 24 bacterial artificial chromosome (BAC) clones that were assembled into the IGH-A (1.
View Article and Find Full Text PDFBackground: We have previously sequenced more than 500 kb of the duplicated MHC class I regions in Atlantic salmon. In the IA region we identified the loci for the MHC class I gene Sasa-UBA in addition to a soluble MHC class I molecule, Sasa-ULA. A pseudolocus for Sasa-UCA was identified in the nonclassical IB region.
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- The study investigates the T-cell receptor gamma (TCRgamma) gene in Atlantic salmon, revealing significant variation in its ability to recognize antigens due to gene segment diversity.
- This is the first comprehensive analysis of the TCRgamma locus in teleost fish, discovering two loci: TCRgamma 1, which is extensive and contains multiple variable, joining, and constant regions, and TCRgamma 2, which has a non-expressed cluster.
- The research also indicates that Atlantic salmon possess a unique T-cell immune response with more constant regions compared to other species, supporting the presence of a functional gammadelta T-cell immune system.
The complete TCR alpha/delta locus of Atlantic salmon (Salmo salar) has been characterized and annotated. In the 900 kb TCR alpha/delta locus, 292 Valpha/delta segments and 123 Jalpha/delta segments were identified. Of these, 128 Valpha/delta, 113 Jalpha, and a Jdelta segment appeared to be functional as they lacked frame shifts or stop codons.
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