Publications by authors named "Linda Mamone"
Background: Anaplasma phagocytophilum is a tick-borne bacterium and the cause of human granulocytic anaplasmosis (HGA). Here, we report a case of transfusion-transmitted (TT)-HGA involving a leukoreduced (LR) red blood cell (RBC) unit.
Case Report: A 64-year-old woman with gastric adenocarcinoma and multiple myeloma who received weekly blood transfusions developed persistent fevers, hypotension, and shortness of breath 1 week after receiving an RBC transfusion.
Article Synopsis
- The study aimed to evaluate the effectiveness of convalescent plasma in increasing antibodies and improving outcomes for COVID-19 patients compared to standard plasma.
- Conducted as a double-blind randomized controlled trial at a New York hospital, 74 patients with confirmed COVID-19 were assigned to receive either convalescent plasma or standard plasma.
- Results showed convalescent plasma increased SARS-CoV-2 antibodies by 14.4%, while standard plasma decreased it by 8.6%; however, both groups had similar rates of ventilator-free days, indicating no significant improvement in primary outcomes.
Background: Convalescent plasma is undergoing randomized trials as a potential therapeutic option for COVID-19 infection. Little empirical evidence exists regarding the determination of donor eligibility and experiences with donor selection.
Study Design And Methods: This prospective study was conducted at a tertiary care hospital in New York to select plasma donors for a randomized, double-blind, controlled convalescent plasma trial.
This case study presents a patient with multiple myeloma whose serum specimen exhibits 2 distinct bands in serum protein electrophoresis but only one band in immunofixation electrophoresis. This latter, single band corresponds to the M-spike. An investigation is presented to determine the identity of this disappearing or phantom band.
View Article and Find Full Text PDFSecondary hemophagocytic lymphohistiocytosis (HLH) is an uncommon, but life-threatening syndrome of highly stimulated and ineffective immune dysregulation. It is not a disease entity by itself and the current diagnosis of secondary (acquired) HLH is based on constellation of nonspecific clinical and laboratory parameters indicative of overactive immune response. The presenting symptoms are often nonspecific and could potentially be missed, leading to a fatal outcome.
View Article and Find Full Text PDFWe report a case of multiple fungal renal abscesses in a 36-year-old woman with a history of diabetes and intravenous substance use disorder. The patient presented with fever and hematuria, and was found to be bacteremic and fungemic. She was initially managed with broad-spectrum antibiotics and antifungals.
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