Detection rate of quadruple-marker screening determined by clinical follow-up and registry data in the statewide California program, July 2007 to February 2009.

Objective: To evaluate the efficiency of California's quadruple-marker screening program and construct receiver-operating characteristic (ROC) curves.

Methods: This study included the screening records of 552 941 women during July 2007 to February 2009. The screen-positive women received clinical follow-up services at state-approved centers.

Triple-marker prenatal screening program for chromosomal defects.

Objective: To examine screening performance of California's triple-marker screening program, using data from a statewide registry for chromosomal defects.

Methods: This study included 752,686 women who received a screening risk and had an expected date of delivery between July 2005 and the end of June 2007. Follow-up diagnostic services for screen-positive women were performed at state-approved centers.