Publications by authors named "Linda M Page"
Article Synopsis
- - The study investigated how intrathecal morphine affects the production of fibroblast-rich masses in guinea pigs and focused on the potential activation of meningeal mast cells and fibroblasts as a response to morphine treatment.
- - Various treatments were tested, including morphine, a biased μ agonist (PZM21), and another agonist (DMT-DALDA), with results showing that only morphine consistently produced significant fibroblast masses and mast cell activation.
- - The findings suggest that unique mechanisms are in play with morphine, as opposed to other opioids, indicating a distinct pathway linked to fibroblast proliferation possibly mediated by mast cell degranulation and G protein-coupled receptor signaling.
Background: We determined whether intrathecally delivering the same daily dose of morphine (MS) at a fixed concentration of 25 mg/mL by periodic boluses versus continuous infusion would reduce intrathecal mass (IMs) formation in dogs.
Methods: Adult dogs (hound cross, n = 32) were implanted with intrathecal catheters connected to SynchroMed II infusion pumps. Animals were randomly assigned to receive infusion of 0.
Background: Intrathecal infusion of opioids in dogs, sheep, and humans produces local space-occupying masses. To develop a small-animal model, the authors examined effects of intrathecal catheterization and morphine infusion in guinea pigs.
Methods: Under isoflurane, polyethylene or polyurethane catheters were advanced from the cisterna magna to the lumbar enlargement.
Background: Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal trial.
Methods: The authors examined the safety and efficacy of intrathecal gabapentin in a randomized, blinded, placebo-controlled, multicenter trial in a heterogeneous cohort of candidates with chronic pain for intrathecal drug therapy.
Objectives: The phenomenon of inflammatory masses at the tips of intrathecal drug administration catheters was the subject of a recent case-compilation report and a number of animal studies. We sought to synthesize current clinical and preclinical data to formulate hypotheses about the etiology of catheter-tip masses.
Methods: We reviewed the published human clinical data, new unpublished clinical data, and the results of preclinical studies in two mammalian species, beagle dogs and sheep.