Publications by authors named "Linda Hadcocks"
Inhibitory killer cell immunoglobulin-like receptors (iKIRs) are a family of inhibitory receptors that are expressed by natural killer (NK) cells and late-stage differentiated T cells. There is accumulating evidence that iKIRs regulate T cell-mediated immunity. Recently, we reported that T cell-mediated control was enhanced by iKIRs in chronic viral infections.
View Article and Find Full Text PDFIntroduction: The lymphatic system has a pivotal role in immune homeostasis. To better understand this, we investigated the impact of Primary Lymphatic Anomalies (PLA) on lymphocyte numbers and phenotype.
Methods: The study comprised (i) a retrospective cohort: 177 PLA subjects from the National Primary Lymphatic Anomaly Register with clinical and laboratory data, and (ii) a prospective cohort: 28 patients with PLA and 20 healthy controls.
Article Synopsis
- There is evidence that inhibitory killer cell immunoglobulin-like receptors (iKIRs) can influence T cell responses and survival, particularly in chronic viral infections.
- In a study with humans, it was found that individuals with more iKIR-ligand gene pairs had significantly longer-lasting memory CD8+ T cells, with lifespans increasing from 125 days to 250 days.
- The research suggests that iKIR-ligand genotypes play a crucial role in T cell survival and immune aging, independent of iKIR expression on the T cells themselves.
Introduction: Monocyte distribution width (MDW), a parameter generated alongside full blood counts (FBC) in new-generation haematology analysers, has been proposed as a diagnostic test for severe infection/sepsis. It represents the standard deviation (SD) of the monocyte mean volume (MMV).
Methods: This study aimed to compare monocyte volumetric parameters retrieved by the UniCel DxH 900 haematology analyser (MMV and MDW) against corresponding parameters from the same sample measured using flow cytometry (forward scatter [FSC] mean and SD) in combination with phenotypic characterization of monocyte subtypes.
Article Synopsis
- - The study analyzed antibody responses (IgG) in 177 individuals with SARS-CoV-2 infection in London from March to May 2020, linking antibody levels to patient demographics and outcomes.
- - Findings revealed that 2.0%-8.5% of participants did not develop antibodies after 3-6 weeks, and those who did were generally older, had more health issues, and higher inflammatory markers.
- - Additionally, non-White participants had stronger antibody responses that persisted over time, suggesting that serologic assays could help monitor immune responses and inform public health strategies.