Kaposi's sarcoma, epidemiology and clinical characteristics in a tertiary hospital, a cross-sectional study.

Introduction: Kaposi's Sarcoma (KS) is a rare soft tissue tumor linked to human herpesvirus 8 (HHV-8), a recognized oncogenic virus. Five distinct clinical presentations have been identified, with the epidemic type being the most prevalent and notably associated with Human Immunodeficiency Virus (HIV). A delayed diagnosis significantly compromises patient prognosis and survival rates.

[Second joint position paper: Use of isotretinoin in severe acne].

Background: The use of isotretinoin is indicated in the treatment of severe acne; however, its adverse effects are important.

Objective: To update the first Mexican Consensus on the use of isotretinoin in severe acne vulgaris, which took place in 2009.

Methods: It was carried out a literature search between June 2009, and February 2015, in order to evaluate topics to be discussed; materials were sent to the experts to promote the debate among participants.

[Mexican consensus on the diagnosis and treatment of atopic dermatitis in adolescents and adults].

Background: The diagnostic approaches and therapeutic strategies of atopic dermatitis (AD) are generally inconsistent among physicians and health institutions.

Objective: To develop a consensus statement among experts to reduce the variations in practice regarding the diagnosis and treatment of patients ≥ 12 years with AD to improve their care.

Methods: Systematic literature search in PubMed and GREAT.

Three cases of bullous morphea: histopathologic findings with implications regarding pathogenesis.

Bullous morphea is a rare variant and is not frequently reported. We present three cases of bullous morphea. Although lymphangiectases have been suggested as the most likely mechanism for the development of the bullae in cases of morphea, none of the cases presented with lymphangiectases.

An unusual presentation of Takayasu's arteritis in two Mexican siblings.

Takayasu's arteritis (TA) is an idiopathic vasculitis characterized by granulomatous arteritis of the aorta and its main branches. Here we describe two cases with atypical presentation of TA in Mexican siblings. Both patients had pyoderma gangrenosum and pulmonary nodules throughout the course of their disease.

[Position paper about isotretinoin on acne vulgaris].

Isotretinoin was authorized since 1982 for the treatment of acne vulgaris associated to severe cutaneous lesions. It has been used in others clinical conditions in various plans of prescription. Since the Isotretinoin was launched, it caused controversies in our country and around the world, especially in relation with the security.

Response to hydralazine-valproate in a patient with mycosis fungoides.

Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively.

Influence of skin color on the diagnostic utility of clinical acanthosis nigricans to predict insulin resistance in obese patients.

Background: Skin color may influence the presence of acanthosis nigricans (AN) as predictor of insulin resistance (IR). The objective of this study was to determine how skin color influences the diagnostic utility of AN as a marker of IR.

Methods: We designed a cross-sectional study.

Dermatological complications of obesity.

Obesity is a health problem of considerable magnitude in the Western world. Dermatological changes have been reported in patients with obesity, including: acanthosis nigricans and skin tags (due to insulin resistance); hyperandrogenism; striae due to over extension; stasis pigmentation due to peripheral vascular disease; lymphedema; pathologies associated with augmented folds; morphologic changes in the foot anatomy due to excess load; and complications that may arise from hospitalization. Acanthosis nigricans plaques can be managed by improved control of hyperinsulinemia; the vitamin D3 analog calcipitriol has also been shown to be effective.