Publications by authors named "Linda Flade"
Article Synopsis
- The study investigates health-related quality of life (HRQoL) in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency and compares it with primary adrenal insufficiency (PAI) and healthy controls.
- CAH patients reported mild impairments in HRQoL, specifically in three aspects, but did not show significant differences in other assessments compared to healthy controls; however, PAI patients had worse HRQoL across more areas.
- The findings imply that HRQoL in CAH is better than in PAI patients, suggesting that factors other than hormone replacement therapy may influence the quality of life in these patients.
Context: Patients with 21-hydroxylase deficiency (21-OHD) have been shown to develop adrenal adenomas and, in males, testicular adrenal rest tumors (TARTs) at a high percentage.
Objective: The aim of this study was to evaluate the interrelation of adrenal masses and TARTs as well as factors stimulating tumor growth of orthotopic and ectopic adrenal tissue in 21-OHD.
Design: In a cross-sectional study, 26 adult male patients with classic 21-OHD (15 salt wasting, 11 simple virilizing; age range, 18-48 yr) were clinically assessed according to their hormonal control.
Context: Testicular adrenal rest tumors (TARTs) are regarded to contribute to the high prevalence of subfertility in males with congenital adrenal hyperplasia (CAH).
Objectives: Our objectives were to evaluate reduced fecundity and its possible causes in well-controlled adult males with CAH, and to investigate diagnostic tools for improved treatment monitoring with respect to fertility outcomes.
Design: In a cross-sectional study at the Department of Endocrinology at the University Hospital München, Germany, 22 adult male CAH patients (15 salt wasting and seven simple virilizing, age 19-48 yr) were clinically assessed according to their hormonal control.