Publications by authors named "Linda Dalecka"
Article Synopsis
- The study investigates the role of Eda protein in tooth development, specifically focusing on incisor germs in mice and how its absence affects tooth formation.
- Researchers employed 3D reconstruction, expression analysis, cell lineage tracing, and western blotting to analyze the impact of Eda's absence on early tooth development stages.
- Results showed that a lack of Eda led to changes in the expression of key developmental factors, resulting in smaller enamel knots and ultimately causing the formation of hypoplastic incisors.
Pharmacokinetics of Intramuscularly Administered Thermoresponsive Polymers.
Adv Healthc Mater
November 2022
Article Synopsis
- Aqueous solutions of certain polymers can phase separate at higher temperatures, showing potential for biomedical uses such as controlled drug delivery and wound dressing.
- The study focused on the pharmacokinetics of four thermoresponsive polyacrylamides after being injected into mice, revealing that they form drug reservoirs that dissolve over time with varying half-lives based on conditions.
- Additionally, these polymers can create secondary depots in organs like the kidneys and liver, suggesting that their distribution and degradation rates can be optimized for specific medical applications.
Article Synopsis
- The Sprouty family plays a key role in modulating receptor tyrosine kinase (RTK) signaling pathways, and disruptions in their function are linked to structural issues in primary cilia, leading to ciliopathies.
- Transgenic mice lacking Sprouty2 and Sprouty4 show significant defects such as improper bone formation, digit patterning issues, and craniofacial abnormalities, which may be attributed to these ciliopathies.
- The study found that these mutant mice exhibit elongated cilia and increased Hedgehog signaling, suggesting that Sprouty protein deficiency can serve as a model to explore the connection between RTK overactivation and cilia dysfunction during bone development.