Publications by authors named "Linda D Mellby"
Article Synopsis
- - The IMMray PanCan-d test, which combines biomarkers and CA19-9, aims to detect pancreatic ductal adenocarcinoma (PDAC) in blood samples, including those from individuals who can't express CA19-9.
- - In a study involving 586 participants, the test showed 98% specificity and between 85-87% sensitivity for detecting different stages of PDAC compared to high-risk individuals and healthy controls.
- - Excluding samples from individuals believed to be Lewis-null improved the test's sensitivity to 92% while maintaining a high specificity of 99%, highlighting its effectiveness in detecting PDAC.
Purpose: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival of < 10% because of diffuse symptoms leading to late-stage diagnosis. That survival could increase significantly if localized tumors could be detected early. Therefore, we used multiparametric analysis of blood samples to obtain a novel biomarker signature of early-stage PDAC.
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