Publications by authors named "Linda Citterio"
Article Synopsis
- Chronic Pseudomonas aeruginosa infections in cystic fibrosis patients are difficult to treat and can lead to high mortality rates.
- Research shows that this bacteria evolves resistance to antibiotics in predictable ways, resulting in different phenotypic states linked to genetic mutations, particularly in the nfxB gene.
- Analyzing patient isolates over time reveals that targeting these specific bacterial states with tailored antibiotic treatments can potentially enhance treatment outcomes and combat chronic infections.
Stable peptidomimetics mimicking natural antimicrobial peptides (AMPs) have emerged as a promising class of potential novel antibiotics. In the present study, we aimed at determining whether the antibacterial activity of two α-peptide/β-peptoid peptidomimetics against a range of bacterial pathogens was affected by conditions mimicking in vivo settings. Their activity was enhanced to an unexpected degree in the presence of human blood plasma for thirteen pathogenic Gram-positive and Gram-negative bacteria.
View Article and Find Full Text PDFAntimicrobial peptides or their synthetic mimics are a promising class of potential new antibiotics. Herein we assess the effect of the type of cationic side chain (i.e.
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