Publications by authors named "Linda Chiara"
Article Synopsis
- The gastrointestinal tract's unique environment leads to the rapid renewal of the intestinal epithelium, making it a focus for study using innovative models.
- Patient-derived intestinal organoids mimic human intestinal conditions and have potential applications across various research areas, including disease modeling, regenerative medicine, and toxicology.
- Despite their promise, challenges such as ethical issues, tissue collection, and variability in methods may limit their use in broader research and clinical settings.
The correlation between the CCL20/CCR6 axis and autoimmune and non-autoimmune disorders is widely recognized. Inhibition of the CCL20-dependent cell migration represents therefore a promising approach for the treatment of many diseases, such as inflammatory bowel diseases and colorectal cancer. We report herein our efforts to explore the biologically relevant chemical space around the benzofuran scaffold of MR120, a modulator of the CCL20/CCR6 axis previously discovered by our group.
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