Zinc-Modified Titanate Nanotubes as Radiosensitizers for Glioblastoma: Enhancing Radiotherapy Efficacy and Monte Carlo Simulations.

Radiotherapy (RT) is the established noninvasive treatment for glioblastoma (GBM), a highly aggressive malignancy. However, its effectiveness in improving patient survival remains limited due to the radioresistant nature of GBM. Metal-based nanostructures have emerged as promising strategies to enhance RT efficacy.

Luminescence characterization of BioGlass undoped and doped with europium and silver ions.

The objective of this study was to investigate the properties of BioGlass, with and without doping with europium and silver, with a specific focus on its potential application in thermoluminescent (TL) and optically stimulated luminescent (OSL) dosimetry. The structural and optical characteristics of the samples were also analyzed using techniques such as X-ray diffraction (XRD), optical absorption (OA), and fluorescence spectroscopy (FL). An XRD analysis confirmed the amorphous phase of the BioGlass.

Investigation of dosimetric properties of CaSO:Mn phosphor prepared using slow evaporation route.

The objective of this work was to investigate the luminescent properties of CaSO:Mn synthesized by slow evaporation route. The crystalline structure, morphology, thermal and optical properties of the phosphors were characterized by X-ray diffraction analysis (XRD), Scanning electron microscopy (SEM), photoluminescence (PL) and thermogravimetric analysis (TGA). Moreover, using thermoluminescence (TL) and optically stimulated luminescence (OSL) techniques, the dosimetric properties of the phosphors, such as emission spectra, glow curve reproducibility, dose-response linearity, fading of the luminescent signal, variation of the TL intensity with the heating rate, OSL decay curves, correlation between TL and OSL emissions and minimum detectable dose (MDD) were comprehensively investigated.

Unlocking the effect of Li and Ce ions on the thermoluminescence and optically stimulated luminescence signals of the MgBO compound.

Magnesium tetraborate (MgBO) is an example of a material that has attracted the attention of researchers in the field of ionising radiation dosimetry. Several challenges are present in order to achieve considerable advances in luminescence dosimetry. The incorporation of efficient dopants in the host matrix has been an experimentally useful but limited strategy.

EFFECT OF DIFFERENT SOLVENTS ON THE OPTICALLY STIMULATED LUMINESCENCE SIGNAL FROM MGB4O7:CE,LI-LOADED POLYMER FILMS.

The detailed dose analysis at the extremities remains a challenge, without affecting operators' mobility and their tactile sense. Using films loaded with optically stimulated luminescence (OSL) crystals have been studied in order to overcome some of these challenges in 2D dosimetry. In this work, we investigated flexible polymeric films loaded with MgB4O7:Ce,Li to acquire a better understanding of the dependence of the dosimetric signal characteristics on the production process and the influence of using different powder grain sizes.

A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV-Vis spectroscopy.

Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra (Jacq.) K.

Assessment of scattered radiation from hand-held dental x-ray equipment using the Monte Carlo method.

The objective of the present study was to evaluate the intensity and spatial distribution of the scattered radiation caused by the use of hand-held x-ray equipment in the zone occupied by the operator, using the Monte Carlo simulation for radiographic views of the upper and lower incisor teeth, and the consequent evaluation of the equivalent dose in the lens. In order to carry out this evaluation, the geometry of a typical dental facility with plaster walls containing the scattering object was used for the computational scenario implemented for the Monte Carlo method simulation. The PENELOPE code for Monte Carlo simulation of electron and photon transport was used with the radiation beam represented by a 60 kV spectrum, 1.

Evaluation of high-linearity bone radiation detectors exposed to gamma-rays via FTIR measurements.

In radiation physics, the study of new alternative dosimeters is of interest to the growing branch of dosimetric characterization for radiotherapy applications. The goal of this work was to expose bone samples to high doses and evaluate their linearity response to gamma rays. The Fourier Transform Infrared (FTIR) spectrophotometry technique was employed as the evaluation technique, and based on the spectrophotometry absorbance profiles the linearity was assessed based on the following methods: Area Under the Curve (AUC), Wavenumber Method (WM), Partial Component Regression (PCR) and Partial Least-Square Regression (PLSR) methods.

Mass energy absorption coefficients and energy responses of magnesium tetraborate dosimeters for 0.02 MeV to 20 MeV photons using Monte Carlo simulations.

Thermoluminescence dosimeters containing boron, such as magnesium tetraborate (MgBO), are of interest because of their very high sensitivity, near tissue-equivalent absorption coefficients, low cost, easy handling, and very large linearity range for absorbed dose. Another important parameter that should be considered when working with thermoluminescent dosimeter (TLD) is the mass energy absorption coefficient (μ/ρ), which is a close approximation to the energy available for production of chemical, biological and other effects associated with exposure to ionizing radiation, therefore important in estimating dose in medical and health physics. In this study the mass energy absorption coefficients and energy responses of undoped and some doped magnesium tetraborates were calculated by Monte Carlo N-particle transport code for a range of photon energies between 20 keV and 20 MeV.

Monte Carlo modeling of a holder for irradiation of dosimeters in beta radiation beams.

A study of the influence of a dosimetric holder and its cover for the irradiation of the dosimeters in the Beta Secondary Standard BSS2 radiation fields is reported. The correction factors for attenuation or scattering were calculated taking into account the BSS2 beta source energy, as well as the detector source distance. The study and the determination of these factors were carried out using the Monte Carlo Method.

Modelling the absorbed dose rate of the beta standard BSS2 Pm source.

The dosimetric measurements of Pm beta radiation beams have limitations due to their low energy, low dose rate, great dispersion and attenuation in air or tissue. In this work, the Monte Carlo model was developed for a Pm absorbed dose rate determination. This model consists of an extrapolation chamber and a Pm beta radiation source.

Determination of correction factors in beta radiation beams using Monte Carlo method.

The absorbed dose rate is the main characterization quantity for beta radiation. The extrapolation chamber is considered the primary standard instrument. To determine absorbed dose rates in beta radiation beams, it is necessary to establish several correction factors.

Determination of transmission factors in beta radiation beams.

In beta emitters, in order to evaluate the absorbed dose rate at different tissue depths, it is necessary to determine the transmission factors. In this work, the transmission factors determined in beta secondary standard radiation beams are presented. For this purpose, an extrapolation chamber was used.

Occupational exposures during abdominal fluoroscopically guided interventional procedures for different patient sizes - A Monte Carlo approach.

In this study we evaluated the occupational exposures during an abdominal fluoroscopically guided interventional radiology procedure. We investigated the relation between the Body Mass Index (BMI), of the patient, and the conversion coefficient values (CC) for a set of dosimetric quantities, used to assess the exposure risks of medical radiation workers. The study was performed using a set of male and female virtual anthropomorphic phantoms, of different body weights and sizes.

Variance reduction technique in a beta radiation beam using an extrapolation chamber.

This paper aims to show how the variance reduction technique "Geometry splitting/Russian roulette" improves the statistical error and reduces uncertainties in the determination of the absorbed dose rate in tissue using an extrapolation chamber for beta radiation. The results show that the use of this technique can increase the number of events in the chamber cavity leading to a closer approximation of simulation result with the physical problem. There was a good agreement among the experimental measurements, the certificate of manufacture and the simulation results of the absorbed dose rate values and uncertainties.

Study of effective dose of various protocols in equipment cone beam CT.

This study has the purpose of assessing the radiation absorbed dose in organs/tissues and estimating the effective dose using five different models of Cone Beam Computed Tomography equipment using protocols with similar purpose. For this purpose, 26 thermoluminescent dosimeters were inserted in the position of the organs/tissues of a female anthropomorphic phantom. From the measurements the contribution of wT×HT in the organs and tissues the effective dose were calculated.

Assessment of protocols in cone-beam CT with symmetric and asymmetric beams usingeffective dose and air kerma-area product.

This study aims to evaluate and compare protocols with similar purposes in a cone beam CT scanner using thermoluminescent dosimeter (TLD) and the air kerma-area product (PKA) as the kerma index. The measurements were performed on two protocols used to obtain an image of the maxilla-mandible using the equipment GENDEX GXCB 500: Protocol [GX1] extended diameter and asymmetric beam (14cm×8.5cm-maxilla/mandible) and protocol [GX2] symmetrical beam (8.

Measuring output factors and beam profiles formed by multileaf collimators using Fricke gel dosimeter.

The accuracy and precision are necessary factors in radiotherapy, especially for measurements involving output factors and beam profiles; in this case multileaf collimators (MLCs) and dosimeter systems are not employed to obtain an adequate absorbed dose. In this work, output factors and beam profiles using multileaf collimators were obtained through the Fricke Xylenol Gel (FXG) dosimeter irradiated with 6 MV photon beams. From the results, FXG dosimetry demonstrated to be an adequate dosimetric tool for radiotherapy applications using MLC.

Calibration of the 90Sr+90Y ophthalmic and dermatological applicators with an extrapolation ionization minichamber.

(90)Sr+(90)Y clinical applicators are used for brachytherapy in Brazilian clinics even though they are not manufactured anymore. Such sources must be calibrated periodically, and one of the calibration methods in use is ionometry with extrapolation ionization chambers. (90)Sr+(90)Y clinical applicators were calibrated using an extrapolation minichamber developed at the Calibration Laboratory at IPEN.

Fricke dosimeter gel measurements of the profiles of shielded fields.

In radiation therapy, the shielding of normal tissue can be made using Cerrobend® blocks or a multileaf collimator. In this work, profiles of shielded fields collimated by Cerrobend blocks were obtained through the Fricke Xylenol Gel (FXG) dosimeter irradiated with 6 MV photon beams. The results show that the FXG system can be used in profile measurements of small fields in radiotherapy.

TL behavior of topaz-glass composite in various irradiation fields.

Topaz is a natural hard silicate mineral that has the potential to be used as a thermoluminescent dosimeter (TLD). It is difficult to manufacture chips of topaz and problematic to use its powder as TLDs. Topaz-glass composite (in the form of pellets) can be made easily and applied for radiation dosimetry.

PTOSL response of commercial Al2O3:C detectors to ultraviolet radiation.

The photo-transferred optically stimulated luminescence (PTOSL) technique using Al2O3:C detectors has been suggested as a good option for ultraviolet (UV) radiation dosimetry. The objective of this work was to study the PTOSL response of Al2O3:C InLight detectors and the OSL microStar reader of Landauer. The parameters such as radiation pre-dose, optical treatment time and UV illumination time were determined.

Application of extrapolation chambers in low-energy X-rays as reference systems.

Extrapolation chambers are instruments designed to measure doses of low-energy radiations, mainly beta radiation. In this work, a commercial extrapolation chamber and a homemade extrapolation chamber were applied in measurements using standard radiotherapy X-ray beams. Saturation curves and polarity effect as well as short- and medium-term stabilities were obtained, and these results are within the recommendations of the International Electrotechnical Commission (IEC).

Dosimetric characteristics of jasper samples for high dose dosimetry.

Different colored jasper samples from Brazilian mines were powdered and mixed with teflon (composites jasper-teflonTM). This paper describes a preliminary study of a thermoluminescent method (TL) to verify the possibility of their use as high dose dosimeters or irradiation indicators in industrial areas. The jasper samples were exposed to different radiation doses, using the gamma-cell 220 system (60Co) of IPEN.