Publications by authors named "Linda C de Jong"
Potential of PSMA-targeting radioligand therapy for malignant primary and secondary brain tumours using super-selective intra-arterial administration: a single centre, open label, non-randomised prospective imaging study.
Ilanah J Pruis Pieter Jan van Doormaal Rutger K Balvers Martin J van den Bent Anita A Harteveld Linda C de Jong
EBioMedicine
April 2024
Article Synopsis
- The study aimed to evaluate the effectiveness of PSMA-targeting radioligand therapy (RLT) for treating malignant brain tumors and investigated if administering the treatment via super-selective intra-arterial (ssIA) methods could improve drug uptake in tumors.
- Ten patients with brain tumors underwent both intravenous and intra-arterial administration of [Ga]Ga-PSMA-11, with safety monitored and tumor uptake quantified through PET-MRI imaging across different time points.
- Results showed that ssIA administration significantly increased radioligand uptake in tumors (15-fold higher median) compared to intravenous administration, without adverse effects, indicating it may be a promising approach for enhancing treatment options for brain tumor patients.*