Impact of sex on insulin secretion in cystic fibrosis.

Context: Cystic fibrosis-related diabetes is primarily due to a defect in insulin secretion. Women with cystic fibrosis (CF) are at higher risk of developing CF-related diabetes.

Objective: The objective of the study was to examine sex differences in insulin and glucose homeostasis.

Hypertriglyceridemia is associated with insulin levels in adult cystic fibrosis patients.

Background: Recent studies have identified hypertriglyceridemic cystic fibrosis patients (CF-TG). However, whether hypertriglyceridemia is associated with an altered metabolic profile remains unknown.

Objective: To characterize CF-TG and determine whether triglycerides (TG) levels are associated with metabolic alterations.

LDL-cholesterol and insulin are independently associated with body mass index in adult cystic fibrosis patients.

Background: The median life expectancy of cystic fibrosis (CF) patients has increased dramatically over the last few years and we now observe a subset of patients with a body mass index (BMI) exceeding 25 kg/m(2). The aim of this study was to characterize these individuals and to identify factors associated with higher BMI.

Methods: This is a cross sectional study including 187 adult CF subjects.