Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography.

In this study, we aim to validate the analytical Cramer-Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm for intralipid samples.

Towards non-invasive tissue hydration measurements with optical coherence tomography.

The attenuation coefficient ( ) measured by optical coherence tomography (OCT) has been used to determine tissue hydration. Previous dual-wavelength OCT systems could not attain the needed precision, which we attribute to the absence of wavelength-dependent scattering of tissue in the underlying model. Assuming that scattering can be described using two parameters, we propose a triple/quadrupole-OCT system to achieve clinically relevant precision in water volume fraction.

Accuracy and precision of depth-resolved estimation of attenuation coefficients in optical coherence tomography.

Significance: Parametric imaging of the attenuation coefficient using optical coherence tomography (OCT) is a promising approach for evaluating abnormalities in tissue. To date, a standardized measure of accuracy and precision of by the depth-resolved estimation (DRE) method, as an alternative to least squares fitting, is missing.

Aim: We present a robust theoretical framework to determine accuracy and precision of the DRE of .

Precision of attenuation coefficient measurements by optical coherence tomography.

Significance: Optical coherence tomography (OCT) is an interferometric imaging modality, which provides tomographic information on the microscopic scale. Furthermore, OCT signal analysis facilitates quantification of tissue optical properties (e.g.