Publications by authors named "Linda Ann Smith"

Article Synopsis
  • The study examines the potential benefits of universal germline testing for all breast cancer patients, particularly focusing on how it may influence clinical decision-making.
  • Researchers assessed data from a cohort of men and women aged 18 to 90 who had not been previously tested for genetic variants, documenting changes to treatment recommendations based on the testing results.
  • Results showed that a significant majority of patients (83.8% in-criteria and 67.6% out-of-criteria) had at least one change in their clinical management following genetic testing, highlighting the practical implications of testing guidelines.
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Purpose: An estimated 10% of breast and ovarian cancers result from hereditary causes. Current testing guidelines for germ line susceptibility genes in patients with breast carcinoma were developed to identify carriers of BRCA1/ 2 variants and have evolved in the panel-testing era. We evaluated the capability of the National Comprehensive Cancer Network (NCCN) guidelines to identify patients with breast cancer with pathogenic variants in expanded panel testing.

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