Publications by authors named "Linda A Murphy"
Objectives: Real-world data (RWD) and real-world evidence (RWE) can provide extensive information on healthcare for use in health technology assessment and decision making. Nevertheless, there is a lack of consensus surrounding the appropriate data governance (DG) practices for RWD/RWE. Data sharing is also a large concern, especially considering evolving data protection regulations.
View Article and Find Full Text PDFObjectives: This study aimed to describe the role of real-world data (RWD) and real-world evidence (RWE) in health technology assessment (HTA) in 5 European countries and to identify the hurdles to the acceptance of RWE and suggest directions toward its more effective use.
Methods: Authors from France, Germany, Italy, and Sweden used a common template to extract evidence. For England, the Cancer Drugs Fund was described and analyzed as a particular model for the use of RWD to provide evidence for coverage decisions and managed entry agreements.
Article Synopsis
- There has been an increasing demand for real-world evidence (RWE) and data (RWD) in the last decade, aiming to expedite the approval of effective medications for patients, especially in regulatory settings.
- However, RWE is often met with skepticism by reimbursement agencies, leading to inconsistent acceptance across different regions and hindering its optimal use despite extensive research on its principles.
- The article proposes creating a repository to document the use of RWD for funding decisions and introduces a structured classification (taxonomy) to help evaluate evidence quality, while also recommending international standards for RWD governance.
This is one of a series of articles that consider the barriers to optimal use of real-world evidence (RWE) in health technology assessment and how to overcome them. The work was performed as part of EUreccA 2025, in particular with the RWE workstream embodied within that collaboration. Elsewhere in this issue we described the reasoning and process that led us to develop practical tools to support RWE use, including this taxonomy and explained the methods used to do so.
View Article and Find Full Text PDFArticle Synopsis
- * The RWE workstream identifies issues with the inconsistent acceptance of RWE by HTA agencies and payers, which affects the speed and cost of pharmaceutical access for patients.
- * The article discusses the methodology used to explore these challenges, highlighting four key topics to tackle barriers and proposing strategies through literature reviews, stakeholder engagement, and case studies.
Self-management (SM) is defined as the provision of interventions to increase patients' skills and confidence, empowering the individual to take an active part in their disease management. There is uncertainty regarding the optimal format and the short- and long-term benefits of chronic obstructive pulmonary disease (COPD) SM interventions in adults. Therefore, a high-quality overview of reviews was updated to examine their clinical effectiveness.
View Article and Find Full Text PDFMedline and Embase were searched for studies comparing robot-assisted radical prostatectomy with open prostatectomy and conventional laparoscopic prostatectomy. Random effects meta-analysis was used to calculate a pooled estimate of effect. The 95% prediction intervals are also reported.
View Article and Find Full Text PDFSuccessful design of components for total shoulder arthroplasty has proven to be challenging. This is because of the difficulties in maintaining fixation of the component that inserts into the scapula; i.e.
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