Publications by authors named "Lincoln Hopkins"
eCD4-immunoglobulin (Ig) is an HIV entry inhibitor that mimics the engagement of both CD4 and CCR5 with the HIV envelope (Env) protein, a property that imbues it with remarkable potency and breadth. However, env is exceptionally genetically malleable and can evolve to escape a wide variety of entry inhibitors. Here we document the evolution of partial eCD4-Ig resistance in SHIV-AD8-infected rhesus macaques (RMs) treated with adeno-associated virus vectors encoding eCD4-Ig.
View Article and Find Full Text PDFChronic emesis (CE) is a poorly understood condition in human and nonhuman primates that negatively impacts the quality of life. Early identification of risk factors for the development of CE is likely to improve the ability to manage CE cases successfully and is, therefore, desirable. Using a case-control study, we reviewed the necropsy records of the California National Primate Research Center and identified 24 animals with recorded CE, defined as five or more incidents of emesis in 1 month.
View Article and Find Full Text PDFArticle Synopsis
- The FDA authorized BNT162b2 and mRNA-1273 vaccines for infants 6 months and older in June 2022, but concerns about their long-term efficacy against new variants remain.
- Previous studies shown that specific vaccine formulations were safe and effective in infant rhesus macaques, demonstrating persistent antibody responses for 12 months.
- When challenged with the Delta variant, vaccinated macaques showed better viral clearance and milder symptoms compared to unvaccinated ones, suggesting that early-life vaccination against SARS-CoV-2 can be beneficial.