Publications by authors named "Linchun Huan"

Background: Statistically, Anterior communicating aneurysm (ACoA) accounts for 30 to 35% of intracranial aneurysms. ACoA, once ruptured, will have an acute onset and cause severe neurological dysfunction and even death. Therefore, clinical analysis of risk factors related to ACoA and the establishment of prediction model are the benefits to the primary prevention of ACoA.

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Objective: Several studies have reported that single-nucleotide polymorphisms (SNPs) of the / gene on chromosome 9p21.3 are associated with increased risk of intracranial aneurysm (IA). However, the association between IAs and SNPs of / in Chinese Han people is yet to be evaluated.

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Purpose: Genetic factors play a vital role in intracranial aneurysm (IA) onset and development. Studying the relationship between IA and the polymorphisms in diverse populations is essential for establishing credibility.

Patients And Methods: We collected blood samples derived from a total of 596 sporadic IA patients and 600 individual controls in several medical institutes in China.

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Background: Intracranial aneurysm (IA) is usually a late-onset disease, affecting 1% to 3% of the general population and leading to life-threatening subarachnoid hemorrhage. Genetic susceptibility has been implicated in IAs, but the causative genes remain elusive.

Methods: We performed next-generation sequencing in a discovery cohort of 20 Chinese IA patients.

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The present case report aimed to improve the understanding of alveolar soft part sarcoma (ASPS) by investigating the clinical characteristics, diagnosis and therapeutic methods used to treat ASPS associated with lung and brain metastases. The clinical data of a single patient diagnosed with ASPS by postoperative pathology was studied retrospectively, and additional associated reports and previous studies of similar cases were reviewed. Clinical symptoms were markedly alleviated following surgical treatment, followed by a chemotherapy regime.

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Hairy and enhancer of split 1 (Hes1), a downstream target of Notch signaling, has long been recognized as crucial in inhibiting neuronal differentiation. However, the role of Hes1 following traumatic brain injury (TBI) in adult neurogenesis in the mouse dentate gyrus (DG) remains partially understood. Here, we investigate the role of Hes1 in regulating neurogenesis in the DG of the adult hippocampus after TBI by up- or downregulating Hes1 expression.

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