Publications by authors named "Linben Xu"
Background: To investigate the regulation mechanism of hematopoiesis of Siwu paste (SWP) in anemia rats, which is a classic Chinese prescription used for nourishing blood or blood deficiency over 1000 years.
Methods: Blood cell and biochemical analysis were used to evaluate the hematopoietic function of SWP in anemia rats. The intestinal microbial composition was analyzed with 16S rRNA gene sequencing, and the metabolites were profiled using UPLC-TripleTOF system nontargeting metabolomics.
Article Synopsis
- - Neuronal-regulated cell death (RCD), primarily caused by reactive oxygen species (ROS) in the central nervous system (CNS), is linked to various CNS diseases, with ferroptosis being one significant nonapoptotic form characterized by lipid damage.
- - Polysaccharides (PCP) have been shown to act as effective antioxidants, providing protective effects against oxidative stress and ferroptosis in microglial cells by activating the NRF2/HO-1 signaling pathway.
- - The findings suggest that PCP not only reduces ROS accumulation but also mitigates ferroptosis in microglia, indicating its potential as a new therapeutic agent for preventing and treating CNS diseases associated with oxidative stress.
Ethnopharmacological Relevance: Siwu Paste (SWP) was recorded in the first national Pharmacopoeia of China, "Tai Ping Hui Min He Ji Ju Fang", it showed excellent effects in regulating all syndromes relevant to blood.
Aim Of The Study: This study aimed to investigate the protective effects of Siwu Paste (SWP) on bone marrow hematopoietic by using rats' model with blood deficiency syndrome induced by chemotherapy.
Materials And Methods: Animal model with blood deficiency syndrome was successfully established by evaluating their peripheral blood cell level and erythrocyte membrane energy metabolism enzyme activity.