[Effect of pentagastrin on the closing pressure of the inferior esophageal sphincter and gastroesophageal reflux].

By means of pull--through perfusion manometry and by means of continuous intraoesophageal pH measurements comparative study on a uniform group of patients (n = 34) has shown that pentagastrin (Acignost R) at a dosage of 6 mg/kg body weight administered subcutaneously increases mean sphincter pressure and total reflux duration.

[Gastric secretion in rats during long-term histamine administration].

The acid--forming, acid--neutralizing functions of the stomach, morphological state of its walls and level of histamine in the blood were studied in control rats and in rats subjected to continuous histamine administration. In the latter, intensive elevation of intragastric acidity in empty stomach, an increase in the histamine contents in the blood, and distrophic processes in the wall of stomach occurred. The functional--morphological data obtained suggest remarkable adaptational abilities of the stomach.

[The effect of atropine on acid formation in the stomach].

In dogs, the effect of atropine on gastric acid secretion induced by food, mechanical stimuli, and histamine involved a complete block of the acid secretion but left the gastric secretory effect of histamine unaffected. Atropine caused about a twofold increase in duration of histamine-evoked acid secretion and a rise of the intragastric acidity in all parts of the stomach.