Dynamics of antiphase bursting modulated by the inhibitory synaptic and hyperpolarization-activated cation currents.

Antiphase bursting related to the rhythmic motor behavior exhibits complex dynamics modulated by the inhibitory synaptic current (), especially in the presence of the hyperpolarization-activated cation current (). In the present paper, the dynamics of antiphase bursting modulated by the and is studied in three aspects with a theoretical model. Firstly, the and the slow with strong strength are the identified to be the necessary conditions for the antiphase bursting.

Bifurcation and pattern dynamics in the nutrient-plankton network.

This paper used a Holling-IV nutrient-plankton model with a network to describe algae's spatial and temporal distribution and variation in a specific sea area. The stability and bifurcation of the nonlinear dynamic model of harmful algal blooms (HABs) were analyzed using the nonlinear dynamic theory and de-eutrophication's effect on algae's nonlinear dynamic behavior. The conditions for equilibrium points (local and global), saddle-node, transcritical, Hopf-Andronov and Bogdanov-Takens (B-T) bifurcation were obtained.

Turing pattern induced by the directed ER network and delay.

Infectious diseases generally spread along with the asymmetry of social network propagation because the asymmetry of urban development and the prevention strategies often affect the direction of the movement. But the spreading mechanism of the epidemic remains to explore in the directed network. In this paper, the main effect of the directed network and delay on the dynamic behaviors of the epidemic is investigated.

Spatiotemporal Patterns in a General Networked Hindmarsh-Rose Model.

Neuron modelling helps to understand the brain behavior through the interaction between neurons, but its mechanism remains unclear. In this paper, the spatiotemporal patterns is investigated in a general networked Hindmarsh-Rose (HR) model. The stability of the network-organized system without delay is analyzed to show the effect of the network on Turing instability through the Hurwitz criterion, and the conditions of Turing instability are obtained.

Pattern mechanism in stochastic SIR networks with ER connectivity.

The diffusion of the susceptible and infected is a vital factor in spreading infectious diseases. However, the previous SIR networks cannot explain the dynamical mechanism of periodic behavior and endemic diseases. Here, we incorporate the diffusion and network effect into the SIR model and describes the mechanism of periodic behavior and endemic diseases through wavenumber and saddle-node bifurcation.

Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.

Aims: Retinal ischemia/reperfusion (I/R) injury is common in the development of ophthalmic diseases and potentially causes blindness. In present study, the aim is to investigate the possible protective effects of puerarin on retinal I/R.

Main Methods: Retinal I/R injury was conducted on the left eyes of male Sprague Dawley rats, which were subsequently received treatment with puerarin.

Rho Kinase Type 1 (ROCK1) Promotes Lipopolysaccharide-induced Inflammation in Corneal Epithelial Cells by Activating Toll-Like Receptor 4 (TLR4)-Mediated Signaling.

BACKGROUND Rho kinases (ROCKs) are the typical downstream effectors of RhoA, which can regulate corneal epithelial wound healing. In this study, the role of ROCK1 in lipopolysaccharide (LPS)-induced cornea inflammation was investigated. MATERIAL AND METHODS The expression of ROCK1 in human corneal epithelial cells (HCECs) was bilaterally modulated with ROCK1 expression vector and ROCK1 inhibitor Y-27632.

Differential proteomic analyses of cataracts from rat models of type 1 and 2 diabetes.

Purpose: To identify differential changes in proteins and metabolites underlying "fast" type 1 (T1DC) and "slow" type 2 (T2DC) diabetic cataract (DC) formation in rat.

Methods: Rat models of types 1 and 2 diabetes consisted of streptozotocin injection without and with high-fat diet, respectively. Cataract progression was examined weekly.

Use of a silk fibroin-chitosan scaffold to construct a tissue-engineered corneal stroma.

Purpose: To construct a scaffold using silk fibroin (SF) and chitosan (CS) that could replace the corneal stroma with the biological characteristics of the scaffold materials still intact.

Methods: To develop an organotypic corneal stroma, SF and CS were chosen to synthesise the tissue-engineered bioscaffold. We cultured primary rabbit corneal epithelial cells and corneal stromal cells in vitro.

Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine.

Purpose: Accumulating evidence in animals suggests that leukocytes are involved in the pathogenesis of diabetic retinopathy. The present study was designed to investigate whether leukocytes from diabetic patients could kill retinal endothelial cells and whether that cytotoxicity could be inhibited in vivo by administration of berberine.

Methods: Human retinal endothelial cells (HRECs) were cocultured (24 h) with leukocytes freshly isolated from nondiabetic and diabetic patients, and leukocyte-mediated death of HRECs was analyzed with flow cytometry.

Chitosan-functionalized silk fibroin 3D scaffold for keratocyte culture.

The goal of this study was to evaluate the potential suitability of an artificial membrane composed of silk fibroin (SF) functionalized by different ratios of chitosan (CS) as a substrate for the stroma of the cornea. Keratocytes were cultured on translucent membranes made of SF and CS with different ratios. The biophysical properties of the silk fibroin and chitosan (SF/CS) membrane were examined.

A C-terminal fragment BIGH3 protein with an RGDRGD motif inhibits corneal neovascularization in vitro and in vivo.

An Arg-Gly-Asp (RGD) motif in the fourth FAS1 domain of the human BIGH3 (transforming growth factor-β1-inducible gene-h3) protein has been reported to play an important role in mediating tumor angiogenesis. The aim of this study was to investigate the inhibitory effect of a modified C-terminal fragment BIGH3 protein with an RGDRGD motif on corneal neovascularization in vitro and in vivo. Recombinant C-terminal fragment BIGH3 protein with wild-type sequence and modified C-terminal fragment BIGH3 protein containing an RGDRGD motif were successfully expressed and purified.

A novel mutation in GJA3 associated with congenital Coppock-like cataract in a large Chinese family.

Purpose: To identify the potential pathogenic mutation over five generations of a Chinese family with congenital Coppock-like cataracts (CCL).

Methods: We investigated five generations of a Chinese family affected with CCL. The family resides in a relatively isolated region of northern China.

A comparison of the effectiveness between amniotic membrane homogenate and transplanted amniotic membrane in healing corneal damage in a rabbit model.

Purpose: To determine whether amniotic membrane homogenate is as effective in healing corneal damage as amniotic membrane transplantation in a rabbit model.

Method: The rabbits were divided into three groups. The cornea of one eye in each rabbit was incised resulting in a defect of approximately 8 mm in diameter.