Objective: A demonstration project of primary human papillomavirus (HPV) testing was initiated in 2011 among more than 23,000 women attending routine cervical cancer screening. We examined the additional diagnostic performance of HPV genotyping for detecting disease in women with abnormal cytology.
Methods: Women aged 30 to 65 years were originally screened for HPV using Hybrid Capture II test.
Purpose: Our laboratory has classified patients with methylmalonic aciduria using somatic cell studies for over four decades. We have accumulated 127 fibroblast lines from patients with persistent elevated methylmalonic acid (MMA) levels in which no genetic cause could be identified. Cultured fibroblasts from 26 of these patients had low [C]propionate incorporation into macromolecules, possibly reflecting decreased methylmalonyl-CoA mutase function.
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