Working hours influence preferences of residents for micro features of small urban green spaces.

This study investigates whether duration of working hours affect residents' preferences for the micro-features of Small Urban Green Spaces (SUGS), and explores differences across genders and visitation purposes. Little is known about this subject, yet it is crucial for creating more equitable green spaces. In phase 1, participants (n = 209; 30.

Paclitaxel-Induced Hepatotoxicity in Ovarian Cancer Patients: A Case Report.

Paclitaxel plus carboplatin is the most common regimen for the treatment of ovarian cancer. While generally effective, these chemotherapy agents can cause adverse events such as myelotoxicity, nausea, vomiting, and rarely, hepatotoxicity. Paclitaxel is associated with mild elevations in serum aminotransferase levels, but significant hepatotoxicity is uncommon, particularly in patients without prior liver disease.

Characterization of the Bioavailability of Per- and Polyfluoroalkyl Substances in Farmland Soils and the Factors Impacting Their Translocation to Edible Plant Tissues.

In this study, various crops and farmland soils were collected from the Fen-Wei Plain, China, to investigate the bioavailability of perfluoroalkyl substances (PFAS), their accumulation in edible plant tissues, and the factors impacting their accumulation. PFAS were frequently detected in all of the crops, with total concentrations ranging from 0.61 to 35.

Phytosterol-mediated glycerosomes combined with peppermint oil enhance transdermal delivery of lappaconitine by modulating the lipid composition of the stratum corneum.

Although the introduction of glycerosomes has enriched strategies for efficient transdermal drug delivery, the inclusion of cholesterol as a membrane stabilizer has limited their clinical application. The current study describes the development and optimization of a new type of glycerosome (S-glycerosome) that is formed in glycerol solution with β-sitosterol as the stabilizer. Moreover, the transdermal permeation properties of lappaconitine (LA)-loaded S-glycerosomes and peppermint oil (PO)-mediated S-glycerosomes (PO-S-glycerosomes) are evaluated, and the lipid alterations in the stratum corneum are analyzed via lipidomics.

Ion-Diffusion Management Enables All-Interface Defect Passivation of Perovskite Solar Cells.

Perovskite solar cells (PSCs) have demonstrated over 25% power conversion efficiency (PCE) via efficient surface passivation. Unfortunately, state-of-the-art perovskite post-treatment strategies can solely heal the top interface defects. Herein, an ion-diffusion management strategy is proposed to concurrently modulate the top interfaces, buried interfaces, and bulk interfaces (i.

Dissolved-Cl triggered redox reaction enables high-performance perovskite solar cells.

Constructing 2D/3D perovskite heterojunctions is effective for the surface passivation of perovskite solar cells (PSCs). However, previous reports that studying perovskite post-treatment only physically deposits 2D perovskite on the 3D perovskite, and the bulk 3D perovskite remains defective. Herein, we propose Cl-dissolved chloroform as a multifunctional solvent for concurrently constructing 2D/3D perovskite heterojunction and inducing the secondary growth of the bulk grains.

Impact Mechanisms of Humic Acid on the Transmembrane Transport of Per- and Polyfluoroalkyl Substances in Wheat at the Subcellular Level: The Important Role of Slow-Type Anion Channels.

Per- and polyfluoroalkyl substances (PFASs) have potential to accumulate in crops and pose health risks to humans, but it is unclear how the widely present organic matters in soil, such as humic acid (HA), affect their uptake and translocation in plants. In this study, hydroponic experiments were conducted to systematically disclose the impacts of HA on the uptake, translocation, and transmembrane transport at the subcellular level of four PFASs, including perfluorooctane sulfonic acid, perfluorooctanoic acid, perfluorohexane sulfonic acid, and 6:2 chlorinated polyfluoroalkyl ether sulfonate in wheat (). The results of the uptake and depuration experiments indicated that HA depressed the adsorption and absorption of PFASs in wheat roots by reducing the bioavailability of PFASs, and HA did not affect the long-range transport of PFASs to be eliminated via the phloem of wheat.

CoO embedded porous biomass-derived carbon as dual-functional host material for lithium-sulfur batteries.

A new strategy is developed to fabricate sulfur electrode by infusing sulfur into a conductive biochar decorated with highly dispersed CoO nanoparticles. The loading of the CoO nanoparticles, as the active sites for reactions, is efficiently increased by using the microwave-assisted diffusion method. It is demonstrated that biochar can serve as an excellent conductive framework to effectively activate sulfur.

Cobalt-free nickel-rich cathode materials based on Al/Mg co-doping of LiNiO for lithium ion battery.

To develop Co-free LiNiO-based layered cathode materials is crucial for meeting the demands of the lithium-ion batteries with high energy density, long cycling life, and low cost. Herein, the LiNiAlMgO materials are synthesized by the solid-solid interface elemental interdiffusion strategy. It is elucidated that the Mg and Al ions are mainly doped in the Li slabs and transition metal slabs, respectively, leading to the alteration of the crystal lattice.

Different Sources, Fractionation, and Migration of Legacy and Novel Per- and Polyfluoroalkyl Substances between Greenhouse and Open-Field Soils.

Perfluoroalkyl substances (PFASs) are widely present in agricultural soils, but their sources and fate in greenhouse soils remain unclear. In this study, the sources, fractionation, and migration of PFASs were compared in the greenhouse and open-field soils of the Fen-Wei Plain, China. The total concentrations of PFASs (ΣPFAS) were comparable in the greenhouse and open-field soils but with different profiles.

Who really benefits from intraperitoneal chemotherapy for advanced ovarian cancer? A treatment-free survival analysis of the AICE trial.

Objective: To investigate whether peritoneal disease extent can predict the survival benefit of intraperitoneal/intravenous (IP/IV) chemotherapy in ovarian cancer.

Design: A treatment-free survival (TFS) analysis.

Setting: Five-centre trial.

Underlying Mechanisms for Low-Molecular-Weight Dissolved Organic Matter to Promote Translocation and Transformation of Chlorinated Polyfluoroalkyl Ether Sulfonate in Wheat.

Dissolved organic matter (DOM) such as fulvic acid (FA) and humic acid (HA) in soil considerably affects the fate of per- and polyfluoroalkyl substances (PFASs). However, the effect of DOM on their behavior in plants remains unclear. Herein, hydroponic experiments indicate that FA and HA reduce the accumulation of an emerging PFAS of high concern, 6:2 chlorinated polyfluoroalkyl ether sulfonate (6:2 Cl-PFESA), in wheat roots by reducing its bioavailability in the solution.

MLife: a lite framework for machine learning lifecycle initialization.

Machine learning (ML) lifecycle is a cyclic process to build an efficient ML system. Though a lot of commercial and community (non-commercial) frameworks have been proposed to streamline the major stages in the ML lifecycle, they are normally overqualified and insufficient for an ML system in its nascent phase. Driven by real-world experience in building and maintaining ML systems, we find that it is more efficient to initialize the major stages of ML lifecycle first for trial and error, followed by the extension of specific stages to acclimatize towards more complex scenarios.

O/W microemulsion droplets diffuse through hydrogel network to achieve enhanced transdermal drug delivery.

To overcome the poor water solubility of total flavones of , microemulsions (MEs) can be used as a carrier for transdermal administration to promote their solubilization and skin permeability. Here, we investigated the physical compatibility of MEs in hydrogels and their skin permeation-enhancing effects. Transparency of microemulsion-based hydrogels (MBGs) was analyzed to evaluate ME compatibility with different hydrogel matrices.

Paclitaxel and naringenin-loaded solid lipid nanoparticles surface modified with cyclic peptides with improved tumor targeting ability in glioblastoma multiforme.

The present work describes the systematic development of paclitaxel and naringenin-loaded solid lipid nanoparticles (SLNs) for the treatment of glioblastoma multiforme (GBM). So far only temozolomide therapy is available for the GBM treatment, which fails by large amount due to poor brain permeability of the drug and recurrent metastasis of the tumor. Thus, we investigated the drug combination containing paclitaxel and naringenin for the treatment of GBM, as these drugs have individually demonstrated significant potential for the management of a wide variety of carcinoma.

[Bioaccumulation Characteristics of Quinolones (QNs) in Dominant Fish Species and Their Correlation with Environmental Factors in Baiyangdian Lake].

In recent years, quinolone antibiotics (QNs), which easily bioaccumulate in aquatic organisms, have been widely detected in lake ecosystems, and the bioaccumulation and trophic transfer behavior are obviously spatiotemporally different. In this study, the bioaccumulation and trophic transfer behavior of fourteen QNs in nine dominant fish species were studied, the correlation with environmental factors was analyzed, and the health risk of QNs was evaluated in Baiyangdian Lake. The results showed that the mass concentrations of ∑QNs in water varied from 0.

The complete chloroplast genome of the extremely drought-resistant plant .

is a perennial herb of Gesneriaceae distributed on the limestone rocks. Here, the complete chloroplast (cp) genome of was assembled and characterized. The cp genome is in a total length of 152,718 bp with the typical quadripartite structure, containing 2 inverted repeats (IRs) of 25,472 bp separated by a large single-copy (LSC) region of 83,615 bp and a small single-copy (SSC) region of 18,159 bp.

The key environmental influencing factors for the change of sediment bacterial community and antibiotics resistance genes in a long-term polluted lake, China.

In order to investigate the key environmental influencing factors for the change of sediment bacterial community structure (BCS) and antibiotics resistance genes (ARGs) in a long-term Quinolone antibiotics (QNs) and heavy metals (HMs) polluted lake, 16S rRNA MiSeq High-throughput Sequencing and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) analysis methods were applied. Baiyangdian lake was subdivided into three habitats: (1) Habitat 1: greatly influenced by municipal wastewater; (2) Habitat 2: mainly impacted by aquaculture sewage and domestic wastewater; and (3) Habitat 3: with the least human activities. Through One-way ANOVA analysis, the results showed that most of QNs and HMs showed significant difference among three habitats.

A preoperative prediction model for predicting coexisting adnexa malignancy of patients with G1/G2 endometrioid endometrial cancer.

Objective: To identify the predictors of coexisting adnexa malignancy (CAM) before surgery for patients with G1/G2 endometrioid endometrial cancer (EEC).

Methods: Patients with G1/G2 EEC who received surgery in Fudan University Shanghai Cancer Center from 1996 to 2017 were enrolled. Univariate and multivariate logistic regression were performed to identify the predictors for CAM, and the nomogram was constructed and evaluated the discrimination and calibration.

Temperature-sensitive gel-loaded composite nanomedicines for the treatment of cervical cancer by vaginal delivery.

In this study, toad venom (TV) and realgar were loaded into a poloxamer 188/407 (F127/F188)-based temperature-sensitive in situ gel (TISG) and encapsulated in solid lipid nanoparticles (TV-SLN) or ground nano-realgar (NR) to improve drug release and reduce local irritation after vaginal administration. The combination of TV-SLN and NR (TV-SLN/NR) greatly enhanced the inhibition of tumor cell proliferation and was most effective at a dose ratio of 2:3 (w/w). After TV-SLN/NR treatment, S and G0/G1 phase arrest were observed in HeLa and SKOV-3 cells and the inhibitory effects on proliferation were stronger than those in the conventional powder group.

Bioaccumulation, trophic transfer, and human health risk of quinolones antibiotics in the benthic food web from a macrophyte-dominated shallow lake, North China.

The bioaccumulation and trophic transfer of 12 Quinolones (QNs) have been studied in a macrophyte dominated lake-Baiyangdian Lake, China. QNs concentrations were detected in surface water, sediments, and 25 biological samples. The average concentrations of QNs varied from 3.

Efficient and Stable Low-Bandgap Perovskite Solar Cells Enabled by a CsPbBr-Cluster Assisted Bottom-up Crystallization Approach.

Recently, low-bandgap formamidinium lead iodide FAPbI-based perovskites are of particular interest for high-performance perovskite solar cells (PSCs) due to their broad spectral response and high photocurrent output. However, to inhibit the spontaneous α-to-δ phase transition, 15-17% (molar ratio) of bromide and cesium or methylammonium incorporated into the FAPbI are indispensable to achieve efficient PSCs. In return, the high bromide content will increase bandgap and narrow the spectral response region.