Publications by authors named "Lina P Spinel"
House dust mites (HDMs) are one of the most significant environmental allergens in the establishment of the so-called "Atopic March." It is known that the immune response to HDM is Th2 dominant, but the innate mechanisms leading to HDM-induced type 2 responses are still not completely understood. A number of innate immune receptors have been implicated in the response to HDM including toll-like receptors, C-type lectin receptors, and protease activated receptors.
View Article and Find Full Text PDFProtein kinase B/AKT has three isoforms (AKT1-3) and is renowned for its central role in the regulation of cell growth and proliferation, due to its constitutive activation in various cancers. AKT2, which is highly expressed in insulin-responsive tissues, has been identified as a primary regulator of glucose metabolism as Akt2 knockout mice (Akt2(-/-)) are glucose-intolerant and insulin-resistant. However, the role of AKT1 in glucose metabolism is not as clearly defined.
View Article and Find Full Text PDFArticle Synopsis
- Pancreatic adenocarcinoma is a lethal cancer linked to KRAS mutations and the activation of AKT isoforms, particularly AKT1 and AKT2, which contribute to tumor development and resistance to treatments.
- The study involved genetically modified mice with mutations in Akt1 and KRas to observe their effects on pancreatic cancer progression and associated changes typical in human cases.
- Findings revealed that the active form of AKT1 works with mutant KRas to speed up cancer development and metastasis, providing a model for better understanding pancreatic cancer biology and developing targeted therapies.