Opposing Effects of Additives in Dry Milling and Tableting of Organic Particles.

Applying additives and excipients during the dry processing of fine particles is a common measure to control the particle-particle interactions, to specifically influence the powder properties and to enhance the process efficiency or product quality. In this study, the impacts of a particulate lubricant, a nano-disperse flow additive and liquid grinding aids on the dry fine milling and subsequent tableting of the ground material were investigated for three different organic model compounds. It is presented that the three additive classes cause varying and partly opposing effects during these process steps.