Correction: Reconstructing the phase of vanadium oxides enables redox-catalysis manipulated reversible sulfur conversion for stable Zn-S batteries.

[This corrects the article DOI: 10.1039/D4SC06593J.].

Multifunctional hydrogel scaffolds based on polysaccharides and polymer matrices promote bone repair: A review.

With the advancement of medical technology, the utilization of bioactive materials to promote bone repair has emerged as a significant research area. Hydrogels, as biomaterials, play a crucial role in bone tissue engineering. These hydrogels exhibit high biocompatibility, providing in vivo ecological conditions conducive to cell survival, and offer substantial advantages in facilitating bone repair.

g-CN modified flower-like CuCoO array on nickel foam without binder for high-performance supercapacitors.

This study investigates the impact of integrating g-CN into CuCoO electrodes on electrochemical performance working as binder-free electrodes. Flower-like CuCoO nanostructures on nickel foam are decorated with few-layer g-CN using a secondary hydrothermal process. The hierarchical g-CN/CuCoO nanoflower electrode demonstrates a specific capacity of 247.

Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model.

Purpose: Aimed to analyze the developmental characteristics of craniofacial structures and soft tissues in children with obstructive sleep apnea (OSA) and to establish and evaluate prediction model.

Methods: It's a retrospective study comprising 747 children aged 2-12 years (337 patients and 410 controls) visited the Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University (July 2017 to March 2024). Lateral head radiographs were obtained to compare the cephalometric measurements.

Fungal secondary metabolites as a potential inhibitor of T315I- BCR::ABL1 mutant in chronic myeloid leukemia by molecular docking, molecular dynamics simulation and binding free energy exploration approaches.

Background: Chronic Myeloid Leukemia (CML) is particularly challenging to treat due to the T315I BCR::ABL1 mutation. Although fungal metabolites are known for their pharmaceutical potential, none are approved for CML. Our study screened approximately 2000 fungal secondary metabolites to discover inhibitors targeting the T315I- BCR::ABL1 mutant protein.

Naked eye three-dimensional teaching assistant system applied to undergraduate medical imaging education: A pilot study.

The traditional approach of using PowerPoint (PPT) presentations in medical imaging theory classes hinders the spatial thinking ability of most students. Consequently, the learning outcomes are often unsatisfactory. This article proposes a naked eye three-dimensional (3D) medical imaging teaching assistant app based on augmented reality (AR) technology to enhance learning interest, teaching interaction, and effectiveness.

Measurement of β-nuclides in various solutions using plastic scintillation microspheres.

Background: Scintillation cocktails cannot directly measure samples with extreme acidity or alkalinity in β-nuclide liquid scintillation analysis. Plastic scintillation microspheres (PSm), as a novel scintillation material, offer the potential to overcome these limitations by allowing direct mixing with a variety of solutions for measurement, particularly in challenging chemical environments.

Results: This study evaluated the performance of PSm in various chemical environments, including four acids (nitric, hydrochloric, sulfuric, and phosphoric acids), an alkaline solution (NaOH), a high-salinity solution, and methanol.

Reconstructing the phase of vanadium oxides enables redox-catalysis manipulated reversible sulfur conversion for stable Zn-S batteries.

The naturally sluggish redox kinetics and limited utilization associated with the sulfur conversion in Zn/S electrochemistry hinder its real application. Herein, we report an phase reconstruction strategy that activates the catalytic activity of vanadium oxides for invoking redox-catalysis to manipulate reversible sulfur conversion. It was identified that the VO@C/S precursor derived from metal organic frameworks could be transformed into VO ·HO@C/S by a facile electrochemical induction process.

Revolutionizing Underwater Sensor Performance: Tackling Rayleigh Scattering Challenges by Pseudo Random Noise.

Traditionally, Rayleigh scattering is thought to only impact fiber sensing system performance when the leading fiber is over 10 km long. However, this report illustrates theoretically and experimentally that Rayleigh scattering cannot be ignored in fiber optic interferometric sensor (FOIS) even with several hundred-meter common leading fiber because of the interaction of Rayleigh backward scattering (RBS) and returning interference signal. Herein, a conceptual framework is developed to elucidate the interaction between RBS and FOIS interference, revealing that, beyond laser monochromacity, the self-correction characteristic of laser pulses also influences coherent superposition.

Development and external validation of a Nomogram to predict obstructive sleep apnea in Children.

Unlabelled: To develop a nomogram model to predict obstructive sleep apnea in children and perform an external validation. 864 children who underwent polysomnography at our hospital were randomly assigned to a training cohort and an internal validation cohort (7:3) and 292 children at another hospital were enrolled for external validation. Logistic regression analyses were performed to explore the risk factors for obstructive sleep apnea.

Building and Verifying a Prediction Model for Deep Vein Thrombosis Among Spinal Cord Injury Patients Undergoing Inpatient Rehabilitation.

Objective: To explore the relevant variables that contribute to deep vein thrombosis (DVT) among spinal cord injury (SCI) patients undergoing inpatient rehabilitation and to build and validate a nomogram model that predicts DVT risk.

Methods: By convenience sampling, 558 SCI patients who were hospitalized at a tertiary-level Grade A general hospital in Anhui Province, China between January 2017 and March 2022 were chosen as the study subjects. They were split into 2 groups at random, one for training (n = 446) and the other for validation (n = 112).

[Construction of OSA-related hypertension prediction model based on nomogram].

This study aimed to construct a risk prediction model for obstructive sleep apnea（OSA） related hypertension based on the nomogram, and to explore the independent risk factors for OSA-related hypertension, so as to provide reference for clinical treatment decision-making. The clinical data of OSA patients diagnosed by polysomnography from October 2019 to December 2021 were collected retrospectively and randomly divided into training sets and validation sets. A total of 1 493 OSA patients with 27 variables were included.

Isoprenaline Inhibits Histone Demethylase LSD1 to Induce Cardiac Hypertrophy.

Histone demethylation in cardiac hypertrophy is poorly understood. This study aims to determine the role of the histone demethylase LSD1 in pathological cardiac hypertrophy. Both isoprenaline (ISO)-treated and transverse aortic constriction (TAC)-treated rats developed hypertrophic hearts.

Genome-Wide Analysis of Caffeoyl-CoA-O-methyltransferase (CCoAOMT) Family Genes and the Roles of in Lignin Synthesis in Cotton.

Caffeoyl coenzyme A-O-methyltransferase (CCoAOMT) has a critical function in the lignin biosynthesis pathway. However, its functions in cotton are not clear. In this research, we observed 50 genes from four cotton species, including two diploids (, 9, and ) and two tetraploids (, 16, and ), performed bioinformatic analysis, and focused on the involvement and functions of in lignin synthesis of .

Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.

By establishing an model of D-Gal-induced brain neuronal cell (HT-22) senescence, it was found that TAX treatment significantly increased the activities of SOD and GSH, while decreasing MDA levels in aging HT-22 cells, indicating that TAX effectively restored the total antioxidant capacity and antioxidant enzyme activity of aging HT-22 cells induced by D-Gal, and attenuated cellular oxidative stress injury. In addition, taxifolin could also protect HT-22 cells from aging by up-regulating SIRT1 while reducing the expression of Ac-p53, indicating that TAX may be an active substance that can effectively delay cell aging.

Prognostic modeling of hepatocellular carcinoma based on T-cell proliferation regulators: a bioinformatics approach.

Background: The prognostic value and immune significance of T-cell proliferation regulators (TCRs) in hepatocellular carcinoma (HCC) have not been previously reported. This study aimed to develop a new prognostic model based on TCRs in patients with HCC.

Method: This study used The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) and International Cancer Genome Consortium-Liver Cancer-Riken, Japan (ICGC-LIRI-JP) datasets along with TCRs.

Development and validation of a functional ability index for older adults: a multicohort study.

Background: The aim of this study was to develop and validate a functional ability index (FAI) that incorporates aspects of intrinsic capacity and environmental factors of older individuals based on the World Health Organization framework of healthy ageing.

Methods: Data of 7016 participants ≥60 years participating in the baseline survey of China Health and Retirement Longitudinal Study was used for the development and internal validation of the FAI. External validation was performed in a separate cohort of 1295 older individuals aged ≥60 years.

"3 + X D" structured report in radiology standardized resident training: Can it meet high-level teaching objectives?

Purpose: To evaluate the impact of the innovative "3 + X D" structured report (SR) designed based on Bloom's taxonomy on the learning outcomes of radiology residents during standardized training.

Methods: This is a prospective study that recruited 120 radiology residents from our hospital between 2020 and 2022. Randomly selected 60 residents from the 2020 grade to constituted the control group, and randomly selected 60 residents from the 2021 grade to formed the experimental group.

Function Impairment Screening Tool predicts eight-year mortality in older adults: Beijing Longitudinal Study of Aging.

Purpose: Function impairment is an early stage of disability in older adults and requires timely intervention. We have previously developed Function Impairment Screening Tool (FIST) based on the Delphi method, which has good reliability and validity, but the predictive effect is unknown. Therefore, we aimed to explore the role of FIST in predicting long-term mortality in community-dwelling older adults.

Metabolomic differences between exanthematous drug eruption and infectious mononucleosis.

Background: Exanthematous drug eruption and infectious mononucleosis (IM) are both exanthematous diseases. Current research on exanthematous drug eruption and IM mainly targets identifying these disorders, the resulting differences at the metabolism level have not yet been systematically analyzed.

Materials And Methods: A total of 30 cases of exanthematous drug eruption and IM, 10 patients without exanthema and 10 healthy volunteers were enrolled, 3 mL of fasting venous blood was collected, the serum metabolite content was detected by gas chromatography-mass spectrometry metabolomics.

A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors.

Existing metabolomic clocks exhibit deficiencies in capturing the heterogeneous aging rates among individuals with the same chronological age. Yet, the modifiable and non-modifiable factors in metabolomic aging have not been systematically studied. Here, a new aging measure-MetaboAgeMort-is developed using metabolomic profiles from 239,291 UK Biobank participants for 10-year all-cause mortality prediction.

Identify Non-mutational p53 Functional Deficiency in Human Cancers.

An accurate assessment of p53's functional statuses is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with non-mutational p53 inactivation which is not detectable through DNA sequencing. These undetected cases are often misclassified as p53-normal, leading to inaccurate prognosis and downstream association analyses.

A Precision Engineered Interleukin-2 for Bolstering CD8+ T- and NK-cell Activity without Eosinophilia and Vascular Leak Syndrome in Nonhuman Primates.

Unlabelled: We have created a precisely pegylated IL-2 [SAR-444245 (SAR'245) or pegenzileukin, previously THOR-707] designed for proliferation of target CD8+ T and NK cells for anticancer activity, with minimal expansion of anti-target regulatory CD4+ T cells (Treg) that counter their action, or eosinophils that trigger vascular leak syndrome (VLS). We performed in vivo studies in nonhuman primates (NHP) to monitor the safety of SAR'245, pharmacokinetic profile, and pharmacodynamic parameters including expansion of peripheral CD8+ T and NK cells, and effects on Tregs and eosinophils. Studies included multiple ascending dosing and repeat dosing with different regimens (QW, Q2W, Q3W and Q4W).

Preparation of sulfated arabinogalactan-loaded hydrogel for wound healing in mouse burn model.

Sulfation of polysaccharides can affect their biological activity by introducing sulfate groups. Skin burns occur regularly and have a great impact on normal survival. In this study, sulfated arabinogalactan (SAG) was prepared by sulfation, and polyvinyl alcohol (PVA) was used to prepare hydrogels for the treatment of scalded skin in mouse.