Ceftazidime/avibactam resistance is associated with PER-3-producing ST309 lineage in Chilean clinical isolates of non-carbapenemase producing .

Introduction: Ceftazidime/avibactam (CZA) is indicated against multidrug-resistant , particularly those that are carbapenem resistant. CZA resistance in producing PER, a class A extended-spectrum β-lactamase, has been well documented . However, data regarding clinical isolates are scarce.

Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles.

Low-density polyethylene composites containing different sizes of calcium oxide (CaO) nanoparticles were obtained by melt mixing. The CaO nanoparticles were synthesized by either the sol-gel or sonication methods, obtaining two different sizes: ca. 55 nm and 25 nm.

A Multicenter Study To Evaluate Ceftaroline Breakpoints: Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage.

Ceftaroline (CPT) is a broad-spectrum agent with potent activity against methicillin-resistant (MRSA). The sequence type 5 (ST5) Chilean-Cordobés clone, associated with CPT nonsusceptibility, is dominant in Chile, a region with high rates of MRSA infections. Here, we assessed the activity of CPT against a collection of MRSA isolates collected between 1999 and 2018 from nine hospitals ( = 320) and community settings ( = 41) in Santiago, Chile, and evaluated performance across testing methodologies.

[Detection of serinocarbapenemases Class A and other mechanisms of enzymatic resistance to β-lactams in enterobacteria strains with diminished susceptibility to carbapenems isolated of patients in a university hospital].

Background: The emergence of carbapenemase mediated resistance in Enterobacteriaceae has a strong clinical impact. This study aimed to do a genotypic and phenotypic characterization of the enzymatic resistance to β-lactams in clinical Enterobacteriaceae isolates with decreased susceptibility to carbapenems in a university medical center in Santiago.

Methods: During April-September 2010 at Hospital Clinico Universidad de Chile, 23 isolates of carbapenem non susceptible Enterobacteriaceae were collected.