Total flavonoids from Rosa rugosa Thunb.: A comprehensive review of its extraction and purification process, chemical composition, biological effect and applications.

Rosa rugosa Thunb. is a kind of traditional Chinese medicine with homology of medicine and food in China for a long history. The total flavonoids from R.

Exo Ⅲ-assisted amplification signal strategy synergized with Au@Pt NFs/CoSe for sensitive detection of enrofloxacin.

Overuse of enrofloxacin (ENR) has posed a potential threat to ecosystems and public health, so it is critical to sensitive and accurate determination of ENR residues. In this work, a novel ultra-sensitive and specific electrochemical aptasensor was fabricated based on the cobalt diselenide loaded gold and platinum nanoflowers (Au@Pt NFs/ CoSe) and Exonuclease III (Exo III)-assisted cycle amplification strategy for the detection of ENR. Au@Pt NFs/ CoSe nanosheets as the substrate material, with large surface area, accelerate electron transfer and attach more DNA probes on the electrode substrate, have effectively enhanced the electrochemical performance of the electrode.

Polycyclic aromatic hydrocarbons in soils of Central Plains Urban Agglomeration, China: The bidirectional effects of urbanization and anthropogenic activities.

To investigate the variations in environmental behavior (levels, distribution, sources, and soil toxicity) of polycyclic aromatic hydrocarbons (PAHs) under the impact of anthropogenic activities during the urbanization process, we collected soil samples from 195 sites in the Central Plains Urban Agglomeration (CPUA), North China, and analyzed 16 U.S. Environmental Protection Agency (EPA) PAH priority pollutants.

Au@ZnNi-MOF labeled electrochemical aptasensor for detection of enrofloxacin based on AuPt@h-CeO/MoS and DNAzyme-driven DNA walker triple amplification signal strategy.

Herein, an aptasensor based on Pb dependent DNAzyme driven DNA Walker with the triple amplification signal strategy was developed for ultrasensitive detection of enrofloxacin (ENR). The composite of Au & Pt coated hollow cerium oxide (AuPt@h-CeO), and polyethyleneimine (PEI) functionalized molybdenum disulfide (PEI-MoS) were used as the substrate material to increase the specific surface area of the electrode and attach more DNA probes. In the presence of ENR, the aptamer can break away from the double-stranded structure, releasing DNAzyme capable of cleaving circular RNA with the help of Pb, which in turn will generate a large number of capture probes that bind the signal probes.

Effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after percutaneous coronary intervention in patients with coronary heart disease: A protocol for systematic review and meta-analysis.

Background: Percutaneous coronary intervention (PCI) is an important means for the treatment of coronary atherosclerotic heart disease and has effectively reduced the mortality of coronary heart disease. However, reperfusion can also cause certain damage to the vascular endothelium, leading to the major adverse cardiovascular events. Compound Danshen dropping pill is a Chinese patent medicine preparation.

Spatiotemporal evolution law and driving force of mining city patterns.

Urban transformation is an inevitable trend for mining cities to achieve sustainable development. Analyzing the spatiotemporal evolution laws and driving mechanisms of mining cities is necessary for providing a scientific basis for their transformation. In this study, Jixi was taken as an example, which is a typical mining city in China.

Weighted gene co-expression network analysis identifies specific modules and hub genes related to Parkinson's disease.

Objective: Parkinson's disease (PD) is one of the most common neurodegenerative diseases. This study aims to screen specific modules and key genes related to PD.

Methods: Gene expression profile data GSE6613 and GSE22491 were downloaded from the Gene Expression Omnibus database.

Exercise-Mediated Alteration of miR-192-5p Is Associated with Cognitive Improvement in Alzheimer's Disease.

Introduction: Physical exercise is an important component of managing Alzheimer's disease (AD). miRNAs can be modulated by exercise intervention.

Objective: The study explored the involvement and potential mechanism of miR-192-5p in the protective effect of physical exercise on AD.

Effects of Infant Formula Supplemented With Prebiotics and OPO on Infancy Fecal Microbiota: A Pilot Randomized Clinical Trial.

Several lines of evidence suggest that the intestinal microbiota plays crucial roles in infant development, and that it is highly influenced by extrinsic and intrinsic factors. Prebiotic-containing infant formula may increase gastrointestinal tolerance and improve commensal microbiota composition. However, it remains unknown whether supplementation of milk-formulas with prebiotics and 1,3-olein-2-palmitin (OPO) can achieve feeding outcomes similar to those of breastfeeding.

Complexes of Th(IV) with neutral O-N-N-O hybrid ligands: a thermodynamic and crystallographic study.

The thermodynamics of Th(iv) complexes with N,N,N',N'-tetramethyl-2,2'-bipyridine-6,6'-dicarboxamide (TMBiPDA) and N,N,N',N'-tetramethyl-1,10-phenanthroline-2,9-dicarboxamide (TMPhenDA) in CH3OH/10%(v)H2O (CH3OH : H2O = 9 : 1 by volume) were determined by spectrophotometry and calorimetry. The ligand TMBiPDA/TMPhenDA coordinates with the central Th atom by the tetradentate (O-N-N-O) mode, which is validated by 1H NMR in solution and crystallography in the solid. The single crystal X-ray diffraction data show that ten-coordinated thorium coordinates with two ligand molecules and two solvent molecules (water or methanol).

An electrochemical aptasensor-based CoP-decorated porous carbon microspheres and AuNRs labelled methylene blue as signal labels for the sensitive detection of PCB77.

In this work, a simple, specific and ultra-sensitive electrochemical aptasensor was successfully developed based on a novel signal reduction strategy for the detection of polychlorinated biphenyls (PCB77). This aptasensor was prepared by the electrodeposition of gold nanoparticles (AuNPs) on an Au electrode (AuE) modified with cobalt phosphide (CoP, a mixture of CoP and CoP) decorated porous carbon microspheres. In this study, the thiolated single-complementary DNA (cDNA) was immobilized on the surface of the modified electrode via the Au-S bond.

Is skeletal muscle loss associated with chemoradiotherapy toxicity in nasopharyngeal carcinoma patients? A prospective study.

Background: Our study explored to investigate whether skeletal muscle loss before concurrent chemoradiotherapy (CCRT) can predict treatment-related toxicity in this population.

Methods: Computed tomography (CT) scan of the third lumbar were used to assess and calculate the SMA (skeletal muscle area), SMI (skeletal muscle index), SMD (skeletal muscle density), SMG (skeletal muscle gauge) and estimate LBM (lean body mass). Handgrip strength (HGS) and daily walk speed were evaluated.

Genetic Variant Identified in a Short Stature Chinese Infant: A Report of Physical Growth in Clinical Spectrum of -Related Disorders.

Say-Barber-Biesecker-Young-Simpson syndrome (SBBYSS, OMIM#603736) and genitopatellar syndrome (GTPTS, OMIM#606170), characterized by global developmental delay/intellectual disability and special clinical manifestations, are two distinct clinically overlapping syndromes caused by truncating sequence variants in the (10q22.2) gene. We detected a heterozygous variant within exon 16 of (Chr10p: 76781966-76781967) in a 7-months-old female infant who showed symptoms of short stature, global developmental delay, blepharophimosis, and lacrimal duct anomalies highly consistent with SBBYSS.

Occurrence and Estrogenic Potency of Bisphenol Analogs in Sewage Sludge from Wastewater Treatment Plants in Central China.

Land application is suggested to be the most economical sludge disposal method but is also a potential source of bisphenol analogs (BPs) to the environment. In this study, BP concentrations in sewage sludge from Henan province ranged from 15.1 to 2237 ng g dw.

ACOX1 destabilizes p73 to suppress intrinsic apoptosis pathway and regulates sensitivity to doxorubicin in lymphoma cells.

Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation.

Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a.

Arbutin (ARB) has been widely used in skin pigmentation disorders. Nevertheless, the involvements of ARB in diabetic nephropathy (DN) are still unknown. We investigated the functions of ARB in high glucose (HG)-induced cell apoptosis and autophagy in HK-2 cells.

Determination of freely dissolved polycyclic aromatic hydrocarbons in human serum using core-shell FeO@polyacrylate magnetic microspheres by exclusive volume effect.

Freely dissolved concentration is an important parameter for evaluating the bioavailability of compounds. Negligible-depletion solid-phase microextraction (nd-SPME) has been widely used for the determination of freely dissolved compounds but suffered from long equilibrium time. Multifunctional mesoporous composite microspheres have large specific surface area and therefore extraction equilibrium could be reached in a short time.

β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1.

Background: Lymphoma is one of the most common hematologic malignancy. Drug resistance is the main obstacle faced in lymphoma treatment. Cancer stem cells are considered as the source of tumor recurrence, metastasis and drug resistance.

Silence of lncRNA GAS5 alleviates high glucose toxicity to human renal tubular epithelial HK-2 cells through regulation of miR-27a.

Renal tubular damage caused by persistent high glucose environment has been found to contribute to diabetic nephropathy. This study explored the effects of lncRNA growth arrest-specific 5 (GAS5) on high glucose-stimulated human renal tubular epithelial HK-2 damage, as well as the possible internal molecular mechanism. Viability and apoptosis of HK-2 cells were assessed with the help of CCK-8 assay and Annexin V-FITC/PI staining, respectively.

Complexation of Lanthanides with N, N, N', N'-Tetramethylamide Derivatives of Bipyridinedicarboxylic Acid and Phenanthrolinedicarboxylic Acid: Thermodynamics and Coordination Modes.

The thermodynamics of Nd(III) and Eu(III) complexes with N, N, N', N'-tetramethyl-2,2'-bipyridine-6,6'-dicarboxamide (TMBiPDA) and N, N, N', N'-tetramethyl-1,10-phenanthroline-2,9-dicarboxamide (TMPhenDA) in CHOH/10%(v)HO solutions were studied. Stability constants and enthalpies of complexation were determined by absorption spectrophotometry, luminescence, and calorimetry. The stability constants of corresponding lanthanide complexes decrease in the order of TMPhenDA > TMBiPDA, while those of the corresponding ligand complexes with lanthanides decrease in the order of Nd(III) > Eu(III).

A structural and thermodynamic study of the complexes of U(vi) with azinecarboxylates.

Complexation of U(vi) with pyridazine-3-carboxylate (PDZ) and pyrazine-2-carboxylate (PAZ) was studied by spectrophotometry, potentiometry and microcalorimetry in 1.0 mol dm-3 NaClO4. Three complexes, [UO2L]+, UO2L2(aq) and [UO2L3]-, were identified and their stability constants (log β) and the corresponding formation enthalpies were determined.

Genetic and phenotypic characteristics of four Chinese families with fundus albipunctatus.

Fundus albipunctatus (FA) is a rare autosomal recessive form of stationary night blindness characterized by the presence of white or white-yellow dots in the perimacular area and the periphery of the retina, with or without macular involvement. In this study, we examined four Chinese families with FA. Patients were given complete ophthalmic examinations, and blood samples were collected for DNA extraction.

Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish.

Nano-scale zinc oxide (nano-ZnO) is widely used in various industrial and commercial applications. However, the available toxicological information was inadequate to assess the potential ecological risk of nano-ZnO to aquatic organisms and the publics. In this study, the developmental toxicity, oxidative stress and DNA damage of nano-ZnO embryos were investigated in the embryo-larval zebrafish, the toxicity of Zn(2+) releasing from nano-ZnO were also investigated to ascertain the relationship between the nano-ZnO and corresponding Zn(2+).

A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice.

Silicosis is a kind of pneumoconiosis caused by inhalation of silica dust, which is characterized by lung fibrosis. The biologically active form of transforming growth factor-beta1 (TGF-beta1) plays a key role in the development of lung fibrosis. CD36 is involved in the transformation of latent TGF-beta1 (L-TGF-beta1) to active TGF-beta1.

Inhibition of latent transforming growth factor-beta1 activation by lentivirus-mediated short hairpin RNA targeting the CD36 gene in NR8383 cells.

CD36, a cell surface receptor for thrombospondin-1 (TSP-1), is believed to interact with latent transforming growth factor-beta1 (L-TGF-beta1) thereby activating its fibrogenic bioactivity. In this study, a lentiviral vector expressing a short hairpin RNA (shRNA) targeting the rat CD36 gene (Lv-shCD36) is developed and tested. To observe the inhibitory effect of Lv-shCD36 on the activation of L-TGF-beta1, a rat alveolar macrophage cell line (NR8383), infected with either Lv-shCD36 or Lv-shCD36-NC (non-silenced control lentivirus), was treated with 0.