Liubao insect tea polyphenols ameliorate DSS-induced experimental colitis by protecting intestinal barrier and regulating intestinal microbiota.

Liubao insect tea (LIT) is a traditional tea produced from the excreta of Hydrillodes repugnalis that are fed with Liubao tea. In this study, LIT polyphenols (LITP) were extracted and identified, mainly consisting of brevifolin carboxylic acid, brevifolin, ellagic acid. The study aimed to explore the therapeutic potential of LITP in experimental colitis induced by dextran sulfate sodium in mice.

Two-dimensional QDs-Co-CuS/TiC/TiO heterojunction with synergistic unsaturated bimetal sites and sulfur vacancies for highly selective photocatalytic CO reduction.

The primary factors that determine the efficiency and selectivity of multi-electron photoreduction of CO include the chemical properties of the active sites, as well as the kinetics of charge separation and transfer. Herein, a novel two-dimensional QDs-Co-CuS/TiC/TiO heterojunction is developed, with Co-CuS quantum dots serving as cocatalysts and TiC MXene as an effective electron transfer channel. The anchoring effect of TiC facilitates the formation of robust TiS bonds with Co-CuS, thereby promoting efficient separation and transfer of photoelectrons to the Co-Cu bimetallic active sites.

Polarized spectral bidirectional reflectance distribution function in visible band based on Cauchy's empirical dispersion equation.

The polarized bidirectional reflectance distribution function (pBRDF) can describe the changes between the Stokes vectors of incident and reflected light. The existing model can only describe the spatial distribution of the target's polarization characteristics at a single wavelength, so further research is needed for the description of the target's polarized spectral characteristics. In this paper, a modified three-component polarized spectral bidirectional reflectance distribution function (pSBRDF) is proposed, which combines Fresnel equation in the specular reflection component with Cauchy's empirical dispersion equation, by introducing the wavelength variable and dispersion constants that do not change with wavelength.

Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors and is Required for Placenta Morphogenesis and Vasculature Formation.

The placenta links feto-maternal circulation for exchanges of nutrients, gases, and metabolic wastes between the fetus and mother, being essential for pregnancy process and maintenance. The allantois and mesodermal components of amnion, chorion, and yolk sac are derived from extraembryonic mesoderm (Ex-Mes), however, the mechanisms contributing to distinct components of the placenta and regulation the interactions between allantois and epithelium during chorioallantoic fusion and labyrinth formation remains unclear. Isl1 is expressed in progenitors of the Ex-Mes and allantois the Isl1 mut mouse line is analyzed to investigate contribution of Isl1 Ex-Mes / allantoic progenitors to cells of the allantois and placenta.

Nucleoporin 93 Regulates Cancer Cell Growth and Stemness in Bladder Cancer via Wnt/β-Catenin Signaling.

Bladder cancer (BLCA) is a prevalent cancer type with an unmet need for new therapeutic strategies. Nucleoporin 93 (Nup93) is implicated in the pathophysiology of several cancers, but its relationship with bladder cancer remains unclear. Nup93 expression was analyzed in TCGA datasets and 88 BLCA patient samples.

Single-double-band switchable optical circular polarizers based on surface plasmon resonance: publisher's note.

This publisher's note reports a correction in Appl. Opt.63, 1153 (2024)APOPAI0003-693510.

Matrix analysis method for evaluation of lens parameters influence in polarization transmission.

Most studies on the influence of lens parameters in polarization transmission have been carried out in the traditional geometric analysis method, which has the problems of low accuracy and complicated calculation. In this paper, taking the Galileo beam expanding system as an example, a matrix analysis method is proposed to characterize the process of polarization transmission, and derived the polarization azimuth deflection equation. The numerical simulations of the matrix analysis method and the geometric analysis method are compared with the Zemax simulations and the experiments.

The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.

Accurate prediction of human pharmacokinetics (PK) remains one of the key objectives of drug metabolism and PK (DMPK) scientists in drug discovery projects. This is typically performed by using in vitro-in vivo extrapolation (IVIVE) based on mechanistic PK models. In recent years, machine learning (ML), with its ability to harness patterns from previous outcomes to predict future events, has gained increased popularity in application to absorption, distribution, metabolism, and excretion (ADME) sciences.

Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.

Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH kinase (BDK)-mediated phosphorylation. Screening efforts to discover BDK inhibitors led to identification of thiophene PF-07208254, which improved cardiometabolic endpoints in mice.

Research on the development and testing methods of physical education and agility training equipment in universities.

Introduction: Because of the problems of insufficient funds and traditional training methods in college sports agile training, an agile training system based on a wireless network was developed to evaluate the effect of improving the sensitive quality of ordinary college students. Based on the ESP-MESH network, the lower computer realizes automatic networking between devices and tests the performance of the mesh network. Fourteen male college students received 9 weeks of agility training, with seven students in each of two groups: traditional agility training and agile equipment training.

Characteristics of corticomuscular coupling during wheelchair Tai Chi in patients with spinal cord injury.

Background: Wheelchair Tai Chi (WCTC) has been proved to have benefits for the brain and motor system of spinal cord injury (SCI) patients. However, the characteristics of corticomuscular coupling during WCTC are scarcely known. We aimed to investigate changes following SCI on corticomuscular coupling, and further compare the coupling characteristics of WCTC with aerobic exercise in SCI patients.

Catalytic performance of Ni-Co/HZSM-5 catalysts for aromatic compound promotion in simulated bio-oil upgrading.

Bio-oil can be used as a substitute for fossil fuels after it is upgraded. Bimetal-modified HZSM-5 catalysts with various Ni-to-Co ratios were prepared to address catalysis problems, including deactivation of the catalysts and low hydrocarbon yields. The catalytic performance of Ni-Co/HZSM-5 in upgrading the simulated bio-oil was investigated with a fixed-bed reactor, and the influence of the loaded duplex metal ratio was also discussed.

Enhancement effect of biochar addition on anaerobic co-digestion of pig manure and corn straw under biogas slurry circulation.

Based on the semi-continuous anaerobic co-digestion (AcoD) reactor, the effects of biochar addition on the internal environmental changes and gas production characteristics were studied under the condition of biogas slurry recirculation. The results showed that the addition of biochar enhanced the degradation and metabolic pathways of acetate and propionate, thereby reducing the concentrations of volatile fatty acids (VFAs), total ammonia and chemical oxygen demand by 55 %, 41 % and 61 %, respectively. The buffer system formed by the combination of NH and VFAs of C-C was also enhanced, thereby improving the stability of the system.

Requirement for PINCH in skeletal myoblast differentiation.

PINCH, an adaptor of focal adhesion complex, plays essential roles in multiple cellular processes and organogenesis. Here, we ablated PINCH1 or both of PINCH1 and PINCH2 in skeletal muscle progenitors using MyoD-Cre. Double ablation of PINCH1 and PINCH2 resulted in early postnatal lethality with reduced size of skeletal muscles and detachment of diaphragm muscles from the body wall.

Soil Nitrogen Content Detection Based on Near-Infrared Spectroscopy.

Traditional soil nitrogen detection methods have the characteristics of being time-consuming and having an environmental pollution effect. We urgently need a rapid, easy-to-operate, and non-polluting soil nitrogen detection technology. In order to quickly measure the nitrogen content in soil, a new method for detecting the nitrogen content in soil is presented by using a near-infrared spectrum technique and random forest regression (RF).

Effects of long-term COVID-19 confinement and music stimulation on mental state and brain activity of young people.

The Corona Virus Disease 2019 (COVID-19) pandemic may have had a negative emotional impact on individuals. This study investigated the effect of long-term lockdown and music on young people's mood and neurophysiological responses in the prefrontal cortex (PFC). Fifteen healthy young adults were recruited and PFC activation was acquired using functional near-infrared spectroscopy during the conditions of resting, Stroop and music stimulation.

The Transverse Bearing Characteristics of the Pile Foundation in a Calcareous Sand Area.

Reviewing literature revealed that the studies on the bearing characteristics of pile foundations mainly focuses on clay, ordinary sand, loess, saline soil, and other areas. However, few studies on the bearing characteristics of the pile foundation in calcareous sand were conducted. Besides, existing traditional studies ignored the variation of soil compression modulus with depth, and the effect of void ratio on the transverse bearing characteristics of the pile foundation in a calcareous sand area were not well understood.

Development and implementation of urinary transporter biomarkers to facilitate assessment of drug-drug interaction.

Novel urinary biomarker evaluation approaches to support inhibition assessment for renal transporters (e.g., OCT2, multidrug and toxin extrusion proteins [MATEs]).

Integrated Modeling of U.S. Agricultural Soil Emissions of Reactive Nitrogen and Associated Impacts on Air Pollution, Health, and Climate.

Agricultural soils are leading sources of reactive nitrogen (Nr) species including nitrogen oxides (NO), ammonia (NH), and nitrous oxide (NO). The propensity of NO and NH to generate ozone and fine particulate matter and associated impacts on health are highly variable, whereas the climate impacts of long-lived NO are independent of emission timing and location. However, these impacts have rarely been compared on a spatially resolved monetized basis.

2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs ( - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).

The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on 27 September to 1 October 2021. Even with a last-minute move from in-person to virtual, an overwhelmingly high number of nearly 900 professionals representing pharma and biotech companies, contract research organizations (CROs), and multiple regulatory agencies still eagerly convened to actively discuss the most current topics of interest in bioanalysis. The 15th WRIB included 3 Main Workshops and 7 Specialized Workshops that together spanned 1 week in order to allow exhaustive and thorough coverage of all major issues in bioanalysis, biomarkers, immunogenicity, gene therapy, cell therapy and vaccines.