Publications by authors named "Lina Imai"
In this study, we have established a Staphylococcus aureus RpoB H481Y mutant strain and demonstrated that it is sensitive to menadione or hydrogen peroxide-induced oxidative stress and exhibits reduced virulence against a silkworm infection model. Furthermore, the reduced virulence of the RpoB H481Y mutant was abrogated in the presence of N-acetylcysteine, a reactive oxygen species scavenger. These results suggest that oxidative stress sensitivity caused by the RpoB H481Y rifampicin resistance mutation attenuates the virulence of S.
View Article and Find Full Text PDFWe previously reported that knockout of the mazG (SA1292) gene decreases Staphylococcus aureus killing activity against silkworms. S. aureus MazG (SaMazG) has a nucleotide pyrophosphatase domain conserved among MazG family proteins, but its biochemical characteristics are unknown.
View Article and Find Full Text PDFArticle Synopsis
- * While traditional mammalian models like mice and rabbits are common, they require large quantities and raise ethical concerns, making alternatives necessary.
- * The review specifically outlines the benefits of various non-mammalian models such as C. elegans, silkworms, fruit flies, zebrafish, and others, detailing their potential in researching bacteria like Staphylococcus aureus and Pseudomonas aeruginosa.