Response to Ovarian Stimulation for Urgent Fertility Preservation before Gonadotoxic Treatment in -Pathogenic-Variant-Positive Breast Cancer Patients.

pathogenic variants increase the risk of developing early and aggressive breast cancers (BC). For these patients, fertility potential can be directly affected by oncologic treatments. In addition, evidence indicates that -mutated women had a significant reduction in their ovarian reserve.

Should Preimplantation Genetic Testing (PGT) Systematically Be Proposed to Pathogenic Variant Carriers?

Over the past years, genes pathogenic variants have been associated to reproductive issues. Indeed, evidence indicate that -mutated patients are not only at higher risk of developing malignancies, but may also present a reduction of the follicular stockpile. Given these characteristics, patients may be candidates to fertility preservation (FP) techniques or preimplantation genetic testing (PGT) to avoid the transmission of this inherited situation.