Publications by authors named "Lina Almind Knudsen"
Article Synopsis
- Inflammatory Bowel Disease (IBD) affects around 0.3% of people globally, with increasing incidence linked to factors like diet, gut microbiota, genetics, and immune response.
- The study investigated the effects of different protein sources—casein versus red meat—on colitis in Abcb1a-deficient mice, assessing how diet and genetics influence gut inflammation and microbiome compositions.
- Results indicated that the lack of the Abcb1a transporter and dietary influences led to significant changes in immune responses and gut microbiota compared to normal mice, highlighting the role of these factors in IBD pathology.
In the development of inflammatory bowel disease (IBD), the gut microbiota has been established as a key factor. Recently, metabolomics has become important for understanding the functional relevance of gut microbial changes in disease. Animal models for IBD enable the study of factors involved in disease development.
View Article and Find Full Text PDFAim: To evaluate ATP-binding cassette (ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer (CRC) development.
Methods: Literature search was conducted on PubMed using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohn's disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein (P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP), Abcb1/Mdr1a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function.
Results: Recently, human studies reported that changes in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC.