Discovery of four new Chinese species of Jacobsonina Hebard, 1929 and Blattella Caudell, 1903 (Blaberoidea: Blattellidae).

In this study, specimens of Blattellidae collected in China in recent years are analyzed by combining molecular data and morphological characters, and four new species of Jacobsonina and Blattella are described, Jacobsonina plicata Yao & Che, sp. nov., Jacobsonina subapiculata Yao & Che, sp.

Tuning architectural organization of eukaryotic P450 system to boost bioproduction in Escherichia coli.

Eukaryotic cytochrome P450 enzymes, generally colocalizing with their redox partner cytochrome P450 reductase (CPR) on the cytoplasmic surface of organelle membranes, often perform poorly in prokaryotic cells, whether expressed with CPR as a tandem chimera or free-floating individuals, causing a low titer of heterologous chemicals. To improve their biosynthetic performance in Escherichia coli, here, we architecturally design self-assembled alternatives of eukaryotic P450 system using reconstructed P450 and CPR, and create a set of N-termini-bridged P450-CPR heterodimers as the counterparts of eukaryotic P450 system with N-terminus-guided colocalization. The covalent counterparts show superior and robust biosynthetic performance, and the N-termini-bridged architecture is validated to improve the biosynthetic performance of both plant and human P450 systems.

Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults.

Introduction: As no standard case definitions for respiratory syncytial virus-associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and community cohorts of adults with RSV-associated symptoms.

Methods: The frequency, sensitivity, and specificity of acute respiratory disease symptoms among hospitalized and community cohorts of adults with RSV were analyzed. RSV-LRTD signs/symptoms assessed included shortness of breath (dyspnea), cough and/or fever, wheezing/rales/rhonchi (abnormal lung sounds by auscultation), sputum production, tachypnea, hypoxemia, and pleuritic chest pain.

First report of Heterakis pedioecetes Mawson, 1956 (Ascaridomorpha: Heterakoidea) and Synhimantus (Dispharynx) nasuta (Rudolphi, 1819) (Spiruromorpha: Acuarioidea) from the Indo-Chinese green peafowl Pavo muticus imperator (Galliformes: Phasianidae).

The Indo-Chinese green peafowl Pavo muticus imperator (Galliformes: Phasianidae) is an endangered bird species. However, our present knowledge of the species composition of nematode parasites of this bird remains limited. In the present study, two nematode parasites Heterakis pedioecetes Mawson, 1956 (Ascaridomorpha: Heterakoidea) and Synhimantus (Dispharynx) nasuta (Rudolphi, 1819) (Spiruromorpha: Acuarioidea) were reported from P.

Tooth movement analysis of maxillary dentition distalization using clear aligners with buccal and palatal mini-screw anchorages: A finite element study.

Objective: To assess the tooth movement trends during the three stages of maxillary dentition distalization with clear aligners (CA) and to compare the efficacy of different mini-screw anchorage systems.

Materials And Methods: Three-dimensional (3D) finite element models of three anchorage systems (A, control group; B, buccal mini-screw anchorage group; C, palatal mini-screw anchorage group) were established. Three stages of simulating maxillary dentition distalization with CA included maxillary molar distalization (stage 1), maxillary premolar distalization (stage 2) and maxillary anterior teeth retraction (stage 3).

177 Lu-FAP-2286 Therapy in a Case of Squamous Lung Cancer.

We reported a 72-year-old man who was diagnosed with squamous lung cancer and received 2 cycles of 177 Lu-FAP-2286 treatment. Radiological remission was observed on follow-up FAP imaging 7 months later with squamous cell carcinoma antigen decreased to normal level. No other abnormality monitored by routine laboratory examination was noted.

Baseline sensitivity and resistance risk of Sclerotinia sclerotiorum to glabridin and the possible anti-fungal mechanism.

Sclerotinia stem rot caused by Sclerotinia sclerotiorum is one of the most serious diseases of oilseed rape. Chemical control is an important method to control this disease, however, development of fungal resistance to commonly used fungicides has led to severe yield losses in recent years. Therefore, development of novel fungicides against S.

Discovery of ElABCG39: a key player in ingenol transmembrane efflux identified through genome-wide analysis of ABC transporters in Euphorbia lathyris L.

Based on transport inhibition and genome-wide analysis, 123 ABC transporters of Euphorbia lathyris were identified, and it was found that the PDR family members ElABCG39 mediated ingenol efflux. Identification of ingenol biosynthetic enzymes and transporters in plant is fundamental to realize its biosynthesis in chassis cells. At present, several key enzymes of the ingenol biosynthesis pathway have been identified, while the mechanisms governing the accumulation or transport of ingenol to distinct plant tissue compartments remain elusive.

Trace alcohol ether electrolytes with dual-site hydrogen bonds and modulated solvation structures for ultralong-life zinc-ion batteries.

Aqueous zinc-ion batteries (AZIBs) are highly regarded for their affordability, stability, safety, and eco-friendliness. Nevertheless, their practical application is hindered by severe side reactions and the formation of zinc (Zn) dendrites on the Zn metal anode surface. In this study, we employ tetrahydrofuran alcohol (THFA), an efficient and cost-effective alcohol ether electrolyte, to mitigate these issues and achieve ultralong-life AZIBs.

Multi-omics pan-cancer analysis reveals the prognostic values and immunological functions of PPA2, with a spotlight on breast cancer.

Background: Recently, the role of inorganic pyrophosphatase 2 (PPA2) has been remaining merely superficial in many tumors. Hence, the aim was to analyze the potential functions of PPA2 in pan-cancer, focusing on its role in breast cancer.

Methods: A systematic pan-cancer analysis conducted primarily utilizing various open databases such as TCGA and GTEx.

Real-world comparative effectiveness of a third dose of mRNA-1273 versus BNT162b2 among adults aged ≥ 65 years in the United States.

Introduction: To compare the real-world effectiveness of a third dose of mRNA-1273 versus a third dose of BNT162b2 against breakthrough COVID-19 hospitalizations among adults aged ≥ 65 years who completed a primary series of an mRNA-based COVID-19 vaccine (regardless of which primary series was received).

Materials And Methods: This observational comparative vaccine effectiveness (VE) study was conducted using administrative claims data from the US HealthVerity database (September 22, 2021, to August 31, 2022). A third dose of mRNA-1273 versus BNT162b2 was assessed for preventing COVID-19 hospitalizations and medically attended COVID-19 among adults aged ≥ 65 years.

Interdependency or submission to authority? The impacts of horizontal and vertical collectivist orientation on vaccine attitudes in mainland China.

Culture has a profound impact on preventive measures during the COVID-19 pandemic. Previous research has revealed that collectivism is associated with more effective responses to COVID-19 on the national or regional level. However, the impact of different components of collectivist orientation on vaccine attitudes remains insufficiently explored on the individual level.

Molecular Mechanism of Fusarium Fungus Inhibition by Phenazine-1-carboxamide.

Fusarium head blight caused by is a devastating disease in wheat that seriously endangers food security and human health. Previous studies have found that the secondary metabolite phenazine-1-carboxamide produced by biocontrol bacteria inhibited by binding to and inhibiting the activity of histone acetyltransferase Gcn5 (FgGcn5). However, the detailed mechanism of this inhibition remains unknown.

Real-World Effectiveness of a Third Dose of mRNA-1273 Versus BNT162b2 on Inpatient and Medically Attended COVID-19 Among Immunocompromised US Adults.

Introduction: Recent data have shown elevated infection rates in several subpopulations at risk of SARS-CoV-2 infection and COVID-19, including immunocompromised (IC) individuals. Previous research suggests that IC persons have reduced risks of hospitalization and medically attended COVID-19 with two doses of mRNA-1273 (SpikeVax; Moderna) compared to two doses of BNT162b2 (Comirnaty; Pfizer/BioNTech). The main objective of this retrospective cohort study was to compare real-world effectiveness of third doses of mRNA-1273 versus BNT162b2 at multiple time points on occurrence of COVID-19 hospitalization and medically attended COVID-19 among IC adults in the United States (US).

Targeted discovery of unusual diterpenoids with anti-fungal activity from the root of Euphorbia lathyris.

Lathyrisone A (1), a diterpene with an undescribed tricyclic 6/6/6 fused carbon skeleton, along with spirolathyrisins B-D (3-5), three diterpenes with a rare [4.5.0] spirocyclic carbon skeleton, and one known compound (2) were isolated from the roots of Euphorbia lathyris.

Mandibular cortical bone remodeling characteristics in patients with extraction: A cone-beam computed tomography study.

Introduction: This study evaluated the labial and lingual cortical bone remodeling characteristics of mandibular central incisors after retraction, which remain controversial among orthodontists.

Methods: Cortical bone remodeling and central incisor movement of 33 patients (aged 23.64 ± 4.

Self-error learning framework-based algorithm for parameter recovery of extended Wiener-Hammerstein systems subject to quantised measurements.

In this study, a novel estimation scheme is proposed for identifying extended Wiener-Hammerstein systems with hysteresis nonlinearity subject to quantised measurements. The proposed scheme is established in a self-error learning framework to achieve high-performance parameter estimation compared with classic error feedback learning estimation algorithms. Initially, the useful identification data can be extracted from contaminated system data by introducing an adaptive filter.

Development and validation of a random survival forest model for predicting long-term survival of early-stage young breast cancer patients based on the SEER database and an external validation cohort.

Young breast cancer (YBC) patients often face a poor prognosis, hence it's necessary to construct a model that can accurately predict their long-term survival in early stage. To realize this goal, we utilized data from the Surveillance, Epidemiology, and End Results (SEER) databases between January 2010 and December 2020, and meanwhile, enrolled an independent external cohort from Tianjin Medical University Cancer Institute and Hospital. The study aimed to develop and validate a prediction model constructed using the Random Survival Forest (RSF) machine learning algorithm.

Desulfurdioxidative N-N Coupling of N-Arylhydroxylamines and N-Sulfinylanilines: Reaction Development and Mechanism.

A highly efficient and chemoselective approach for the divergent assembling of unsymmetrical hydrazines through an unprecedented intermolecular desulfurdioxidative N-N coupling is developed. This metal free protocol employs readily accessible N-arylhydroxylamines and N-sulfinylanilines to provide highly valuable hydrazine products with good reaction yields and excellent functional group tolerance under simple conditions. Computational studies suggest that the in situ generated O-sulfenylated arylhydroxylamine intermediate undergoes a retro-[2π+2σ] cycloaddition via a stepwise diradical mechanism to form the N-N bond and release SO.