Anti-neuroinflammatory andrastin-type meroterpenoids from the marine-derived fungus HNNU w0032.

A new andrastin-type meroterpenoid penimerodione A (), and three known analogues (-), were isolated from the culture of a marine-derived fungus HNNU w0032 by the guidance of MS/MS-based molecular networking. The planar structure of was established by extensive NMR spectroscopic and HRESIMS analyses, and the absolute configuration was elucidated by a single-crystal X-ray diffraction. Compound showed significant inhibitory effect on NO production in LPS-stimulated BV-2 macrophages with an IC value of 5.

Enhanced catalysis of a vanadium-substituted Keggin-type polyoxomolybdate supported on the MO/C (M = Fe or Co) surface enables efficient and recyclable oxidation of HMF to DFF.

In the reaction of oxidizing 5-hydroxymethylfurfural (HMF), attaining high efficiency and selectivity in the conversion of HMF into DFF presents a challenge due to the possibility of forming multiple products. Polyoxometalates are considered highly active catalysts for HMF oxidation. However, the over-oxidation of products poses a challenge, leading to decreased purity and yield.

Substituent Effect to Fine-Tune Energy Levels of Atom-Precise [MoOS ] Modified Copper(I) Thiolate Clusters Boosting Recyclable Photocatalysis.

The propulsion of photocatalytic hydrogen (H ) production is limited by the rational design and regulation of catalysts with precise structures and excellent activities. In this work, the [MoOS ] unit is introduced into the Cu clusters to form a series of atomically-precise Mo -Cu bimetallic clusters of [Cu (MoOS ) (C H (CH )S) (P(C H -R) ) ] ⋅ xCH CN (R=H, CH , or F), which show high photocatalytic H evolution activities and excellent stability. By electron push-pull effects of the surface ligand, highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels of these Mo -Cu clusters can be finely tuned, promoting the resultant visible-light-driven H evolution performance.

The relationship between childhood adversity and problem behavior of new street corner youth on campus: A moderate mediation model.

To explore the impact mechanism of childhood adversity on problem behaviors of new street corner youth on campus, we surveyed 637 new street corner youth on campus and completed the Strengths and Difficulties Questionnaire, the Childhood Environment Scale, the Life History Strategies Scale, and the Dark Triad Scale. After controlling for gender and age of new street corner youth on campus, results revealed that childhood adversity was significantly and positively associated with problem behaviors. Mediation analysis showed that life history strategy mediated the association between childhood adversity and problem behaviors.

Manipulation of the MoO/MoSe Heterointerface Boosting High Rate and Durability for Sodium/Potassium Storage.

The main challenge for sodium/potassium ion storage is to find the suitable host materials to accommodate the larger-sized Na/K and conquer the sluggish chemical kinetics. Herein, by selenation of polyoxometalate in electrospinning fiber, a novel MoO/MoSe heterostructure embedded in one-dimensional (1D) N,P-doped carbon nanofiber (MoO/MoSe@NPC) is rationally constructed to show distinct enhancement of rate performance and cycle life for sodium ion batteries (SIBs) and potassium ion batteries (PIBs). The 1D skeleton of MoO/MoSe@NPC decreases the diffusion pathway of Na/K, and the doping of N/P heteroatoms in carbon fiber creates abundant active sites and provides good reachability for Na/K transportation.

Graphene-supported polyoxometalate entrapped in a MIL-88A network with highly efficient conversion of polysulfides in Li-S batteries.

It has been demonstrated that polyoxometalates (POMs) have strong anchoring abilities with efficient catalysis of lithium polysulfides (LiPSs). However, the severe aggregation that buries the effective active sites of POMs along with poor electrical conductivity limits the practical application of POMs in lithium sulfur batteries (LSBs). In our strategy, we utilized reduced graphene oxide (rGO) to support a POM catalyst entrapped in a MIL-88A(FeCo) network with a hollow shell skeleton as the sulfur host material.

Application of Dexmedetomidine combined with Propofol Intravenous Anesthesia in Laparoscopic Day Surgery in Pediatric Urology.

Objectives: To evaluate the sedative and analgesic effects of dexmedetomidine combined with propofol intravenous anesthesia in laparoscopic day surgery in pediatric urology.

Methods: Eighty male children with cryptorchidism and hydrocele who underwent laparoscopic daytime surgery in our hospital from January 2019 to January 2021 were selected and randomly divided into two groups: the experimental group and the control group. Children in the experimental group ranged in age from 5.

A 20-core copper(I) nanocluster as electron-hole recombination inhibitor on TiO nanosheets for enhancing photocatalytic H evolution.

For the design of atom-precise copper nanoclusters, besides the exploration of their aesthetic cage-like architectures, their structural modulation and potential applications are being extensively explored. Herein, an atom-precise 20-core copper(I)-alkynyl nanocluster (UJN-Cu20) protected by ethinyloestradiol ligands issynthesized. By virtue of outer-shell hydroxyl groups, UJN-Cu20 could be uniformly modified on the surface of TiO nanosheets hydrogen bonding interactions, thus forming an efficient nanocomposite photocatalyst for hydrogen evolution.

Image reconstruction with the chaotic fiber laser in scattering media.

The reconstruction of the size, position, optical properties, and structure of the object in scattering media was realized with a chaotic fiber laser. The light from the chaotic fiber laser was split into two parts. One part was used as the detection signal to detect the object, and the other was used as the reference signal; then, the two signals were cross correlated.

ZG02 Improved Hepatic Glucose Metabolism and Insulin Sensitivity via Activation of AMPK/Sirt1 Signaling Pathways in a High-fat Diet/Streptozotocin-induced Type 2 Diabetes Model.

Purpose: The aim of the present study was to investigate the hypoglycemic activity and potential mechanism of tetrahydrocarbazole derivatives ZG02 in high-fat diet/streptozotocin-induced type 2 diabetes model.

Methods: C57BL/6 mice (n=30) were randomly assigned to three groups: control group (n=10) was fed with normal diet, the diabetes group (n=10) was fed with high-fat diet for eight weeks followed by intraperitoneal injection of streptozotocin (25 mg/kg) and the ZG02 group (n=10) injected intraperitoneally with ZG02 (30 mg/kg/day) for two weeks after successful modeling. The changes of weight, fasting blood glucose, oral glucose tolerance and fasting blood insulin levels in each group were evaluated.

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment.

Background: Early neurologic deterioration (END) may occur in patients with anterior circulation ischemic stroke (ACIS) after receiving endovascular treatment (EVT). Hemodynamic insufficiency, re-occlusion, and post-re-canalization hyper-perfusion are likely to play a critical role in END. We hypothesized that hemodynamic changes can predict END in patients with ACIS post-successful EVT using trans-cranial Doppler (TCD).

An Investigation and Suggestions for the Improvement of Brain Death Determination in China.

Background: Brain death is the irreversible cessation of the function of the brain including the brainstem. In 2013, the Brain Injury Evaluation Quality Control Centre (BQCC) of the National Health and Family Planning Commission issued criteria and practical guidelines for the determination of brain death. This study aimed to evaluate whether the institutions have adopted these guidelines and to make suggestions for the improvement of the current criteria and practical guidelines for brain death determination in China.

A new xanthone glycoside from .

A new xanthone glycoside, 3,5,7,8-tetramethoxyxanthone-1---D-glucopyranoside (), along with five known compounds, mangiferin (), kaempferol (), quercetin (), chlorogenic acid () and diploptene (), was isolated from the whole plants of (Bak.) Ching. The structure of compound was established on the basis of extensive spectroscopic analyses and chemical methods.

Study of Simplified Coma Scales: Acute Stroke Patients with Tracheal Intubation.

Background: Whether the Glasgow Coma Scale (GCS) can assess intubated patients is still a topic of controversy. We compared the test performance of the GCS motor component (GCS-M)/Simplified Motor Score (SMS) to the total of the GCS in predicting the outcomes of intubated acute severe cerebral vascular disease patients.

Methods: A retrospective analysis of prospectively collected observational data was performed.

Early Neurological Deterioration after Recanalization Treatment in Patients with Acute Ischemic Stroke: A Retrospective Study.

Background: Early neurological deterioration (END) is a prominent issue after recanalization treatment. However, few studies have reported the characteristics of END after endovascular treatment (EVT) as so far. This study investigated the incidence, composition, and outcomes of END after intravenous recombinant tissue plasminogen activator (IV rt-PA) and EVT of acute ischemic stroke, and identified risk factors for END.

Serum and Liver Tissue Metabonomic Study on Fatty Liver in Rats Induced by High-Fat Diet and Intervention Effects of Traditional Chinese Medicine Qushi Huayu Decoction.

Qushi Huayu Decoction (QSHY), clinically derived, consists of five crude drugs, commonly used in treating fatty liver in a clinical setting. However, little is known about its metabolomics study. Herein, the serum and liver tissue metabolomics approach, based on gas chromatography coupled to spectrometry (GC/MS), was employed to evaluate the efficacy and the mechanism underlying QSHY in a rat model of high-fat diet-induced fatty liver.

Dysregulation of TMPRSS3 and TNFRSF11B correlates with tumorigenesis and poor prognosis in patients with breast cancer.

The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis. Then, the differential expression in breast cancer vs.

Villosiclava virens infects specifically rice and barley stamen filaments due to the unique host cell walls.

Rice false smut, caused by the fungal pathogen Villosiclava virens, is one of the most important rice diseases in the world. Previous studies reported that the pathogen has less number of cell wall-degraded genes and attacks dominantly rice stamen filaments and extends intercellularly. To reveal why the fungus infects plant stamen filaments, inoculation test on barley was carried out with the similar protocol to rice.

SUVmax and Tumor Size Predict Surgical Outcome of Synchronous Multiple Primary Lung Cancers.

To assess surgical outcomes in synchronous multiple primary lung cancer (SMPLC) and correlations with clinicopathological features and prognostic/predictive factors.We retrospectively reviewed patients diagnosed with early-stage nonsmall cell lung cancer (NSCLC) between January 2006 and June 2012. In total, 564 patients with resectable NSCLC underwent a preoperative positron emission tomography-computed tomography scan followed by anatomic resection.

In Vitro Antioxidant Activities and in Vivo Anti-Hypoxic Activity of the Edible Mushroom Agaricus bisporus (Lange) Sing. Chaidam.

With the rising awareness of a healthy lifestyle, natural functional foods have gained much interest as promising alternatives to synthetic functional drugs. Recently, wild Agaricus bisporus (Lange) Sing. Chaidam has been found and artificially cultivated for its thick fresh body and excellent taste, with its antioxidant and anti-hypoxic abilities unknown.

Comprehensive comparison of three different immunosuppressive regimens for liver transplant patients with hepatocellular carcinoma: steroid-free immunosuppression, induction immunosuppression and standard immunosuppression.

The different choices of immunosuppression (IS) regimens influenced the outcomes of liver transplantation. Steroid was applied as a standard IS to prevent and treat rejections. However, steroid-related complications were increasingly prominent.

Optimization of culture medium compositions for gellan gum production by a halobacterium Sphingomonas paucimobilis.

The effect of culture medium compositions on gellan gum production produced by fermentation with a halobacterium Sphingomonas paucimobilis QHZJUJW CGMCC2428 was studied. In this work, a fractional factorial design was applied to investigate the main factors that affected gellan gum production by S. paucimobilis QHZJUJW CGMCC2428.

Applications and mechanisms of ionic liquids in whole-cell biotransformation.

Ionic liquids (ILs), entirely composed of cations and anions, are liquid solvents at room temperature. They are interesting due to their low vapor pressure, high polarity and thermostability, and also for the possibility to fine-tune their physicochemical properties through modification of the chemical structures of their cations or anions. In recent years, ILs have been widely used in biotechnological fields involving whole-cell biotransformations of biodiesel or biomass, and organic compound synthesis with cells.