Publications by authors named "Lin-hui Wang"

Article Synopsis
  • This study investigates tertiary lymphoid structures (TLSs) and tumor-infiltrating lymphocytes (TILs) in clear cell renal cell carcinoma (ccRCC), highlighting their roles in the tumor microenvironment.
  • The analysis of 754 ccRCC patients revealed that the presence of mature TLSs is linked to better overall survival, while a high number of scattered TILs is associated with poor prognosis.
  • Findings indicate that abundant and mature TLSs correlate with improved therapy response and decreased risk of relapse, underlining the complex relationship between immune structures and cancer progression.
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Neoadjuvant tyrosine kinase inhibitor (TKI) therapy is an important treatment option for advanced renal cell carcinoma (RCC). Many RCC patients may fail to respond or be resistant to TKI therapy. We aimed to explore the key mechanisms of neoadjuvant therapy résistance.

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Introduction: Neonatal stress disrupts brain development and increases the risk of neurological disorders later in life. However, the impact of neonatal stress on the development of the glymphatic system and susceptibility to Parkinson's disease (PD) remains largely unknown.

Methods: Neonatal maternal deprivation (NMD) was performed on mice for 14 consecutive days to model chronic neonatal stress.

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Background: The glymphatic system is reportedly involved in Parkinson's disease (PD). Based on previous studies, we aimed to confirm the correlation between the glymphatic system and PD progression by combining two imaging parameters, diffusion tensor image analysis along the perivascular space (DTI-ALPS), and enlarged perivascular spaces (EPVS).

Methods: Fifty-one PD patients and fifty healthy control (HC) were included.

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Transition metal chalcogenides as potential anodes for lithium-ion batteries have been widely investigated. For practical application, the drawbacks of low conductivity and volume expansion should be further overcome. Besides the two conventional methods of nanostructure design and the doping of carbon-based materials, the component hybridization of transition metal-based chalcogenides can effectively enhance the electrochemical performance owing to the synergetic effect.

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Background: Laparoendoscopic single-site (LESS) surgery is performed to further narrow the incisions and reduce tissue injury. It has been more than10 years since the surgery was first described. However, there is still no report on the results of 10-year follow-up.

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The glymphatic system contributes to the clearance of amyloid-β from the brain and is disrupted in Alzheimer's disease. However, whether the system is involved in the removal of α-synuclein (α-syn) and whether it is suppressed in Parkinson's disease (PD) remain largely unknown. In mice receiving the intranigral injection of recombinant human α-syn, we found that the glymphatic suppression via aquaporin-4 (AQP4) gene deletion or acetazolamide treatment reduced the clearance of injected α-syn from the brain.

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Accumulating evidence indicates that the glymphatic system has a critical role in maintaining brain homeostasis. However, the detailed anatomy of the glymphatic pathway is not well understood, mostly due to a lack of high spatial resolution 3D visualization. In this study, a fluorescence micro-optical sectioning tomography (fMOST) was used to characterize the glymphatic architecture in the mouse brain.

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Aims: Gao-Zi-Yao has long been a unique way for treating various diseases. The present study is to explore the effect of Gao-Zi-Yao on learning and memory function in old spontaneous hypertensive rats (SHR) and its possible mechanism.

Method: Male old SHR were received different doses of Gao-Zi-Yao for 4 weeks.

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Background: To investigate the learning curve of conformal sphincter preservation operation (CSPO) in the treatment of ultralow rectal cancer and to further explore the influencing factors of operation time.

Methods: From August 2011 to April 2020, 108 consecutive patients with ultralow rectal cancer underwent CSPO by the same surgeon in the Department of Colorectal Surgery of Changhai Hospital. The moving average and cumulative sum control chart (CUSUM) curve were used to analyze the learning curve.

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Nickel sulfide has been widely studied as an anode material for lithium-ion batteries due to its environmental friendliness, low cost, high conductivity, and high theoretical capacity. A simple hydrothermal method was used to prepare NiS nanospheres materials with the size in the range of 100-500 nm. The NiS nanospheres electrodes exhibited a high reversible capacity of 1402.

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In order to solve the poor cycle stability and the pulverization of cobalt sulfides electrodes, a series of amorphous and crystalline cobalt sulfides were prepared by one-pot solvothermal synthesis through controlling the reaction temperatures. Compared to the crystalline cobalt sulfide electrodes, the amorphous cobalt sulfide electrodes exhibited superior electrochemical performance. The high initial discharge and charge capacities of 2,132 mAh/g and 1,443 mAh/g at 200 mA/g were obtained.

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Due to the high theoretical capability, copper-based oxides were widely investigated. A facile water bath method was used to synthesis CuO nanowires and CuO/CuO/Cu nanocomposites. Owing to the synergetic effect, the CuO/CuO/Cu nanocomposites exhibit superior electrochemical performance compared to the CuO nanowires.

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Introduction: The classical pathway for the therapy of low- to intermediate-risk localized prostate cancer is radical prostatectomy or radiation therapy, which has shown a high incidence of complications, including erectile dysfunction, urinary incontinence, and bowel injury. An alternative pathway is to perform an ablation by some energy to the localized lesion, known as focal therapy. High-frequency irreversible electroporation (H-FIRE) is nonthermal energy that can be used in cancer ablation to deliver pulsed high-voltage but low-energy electric current to the cell membrane and to invoke cell death.

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Introduction: Prostate biopsy (PB) is a typical daily practice method for the diagnosis of prostate cancer (PCa). This study aimed to compare the PCa detection rates and peri- and postoperative complications of PB among 3 residents and a consultant.

Patients And Methods: A total of 343 patients who underwent PB between August 2018 and July 2019 were involved in this study.

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Article Synopsis
  • Autophagy plays a potential role in the development of human embryonic kidneys, with changes in autophagy-related gene expression observed during this process.
  • Researchers identified 36,151 renal cells from embryonic kidneys using single-cell RNA sequencing, discovering that nephron progenitors exhibit varying levels of autophagy depending on SIX2 expression.
  • The study indicates that autophagy contributes to cellular differentiation and complexity, particularly seen in the context of Wilms tumor, suggesting its importance in early kidney development.
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To evaluate outcomes between extraperitoneal robotic single-port radical prostatectomy (epR-spRP) and extraperitoneal robotic multiport radical prostatectomy (epR-mpRP) performed with the da Vinci Si Surgical System, comparison was performed between 30 single-port (SP group) and 26 multiport (MP group) cases. Comparisons included operative time, estimated blood loss (EBL), hospital stay, peritoneal violation, pain scores, scar satisfaction, continence, and erectile function. The median operation time and EBL were not different between the two groups.

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Background: Signal transduction of Angiotensin II (Ang II) induced autophagy and its role in Ang II-induced dysfunction of HUVECs are still unclear.

Methods: HUVECs are stimulated with different doses of Ang II (10-9-10-5 mol/L) for different time (6-48 hours). Autophagy-related protein markers: LC3, Beclin-1 and SQSTM1/p62 are measured by western blot.

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CuS and CuS have been investigated respectively as anodes of lithium-ion batteries because of their abundant resources, no environment pollution, good electrical conductivity, and a stable discharge voltage plateau. In this work, CuS/CuS nanocomposites were firstly prepared simultaneously by the one-pot synthesis method at a relatively higher reaction temperature 200 °C. The CuS/CuS nanocomposites anodes exhibited a high initial discharge capacity, an excellent reversible rate capability, and remarkable cycle stability at a high current density, which could be due to the nano-size of the CuS/CuS nanocomposites and the assistance of CuS.

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Following intrathecal injection of fluorescent tracers, ex vivo imaging of brain vibratome slices has been widely used to study the glymphatic system in the rodent brain. Tracer penetration into the brain is usually quantified by image-processing, even though this approach requires much time and manual operation. Here, we illustrate a simple protocol for the quantitative determination of glymphatic activity using spectrophotofluorometry.

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Background: Pulmonary hypertension (PH) remains a prevalent disease globally. Sodium tanshinone II sulfonate A (STS) has been used in clinical treatment of PH.

Aims: The aim of the present study was to investigate the effect of sodium STS treatment on hypoxia-induced PH and related mechanisms.

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Aims: The arcuate nucleus is a vital brain region for coursing of pain command. G protein-coupled kinase 6 (GRK6) accommodates signaling through G protein-coupled receptors. Studies have demonstrated that GRK6 is involved in inflammatory pain and neuropathic pain.

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