Chemometric Classification of Different Tree Peony Species Native to China Based on the Assessment of Major Fatty Acids of Seed Oil and Phenotypic Characteristics of the Seeds.

In the present study, we quantitatively measured five major fatty acids (FA) in seed oil using gas chromatography/mass spectrometry (GC/MS) and examined four phenotypic characteristics of the seeds from 19 populations from nine wild tree peony species native to China. The results showed that the unsaturated FAs contents were dominant, of which α-linolenic acid (ALA), linoleic acid, and oleic acid (OA) contents ranged from 14.84 to 42.

[Reconstructive approaches of alimentary canal for subtotal gastrectomy].

Objective: To explore the optimal technique of digestive tract reconstruction for radical proximal gastrectomy.

Methods: The clinical data for 120 cases of proximal gastric cancer undergoing radical proximal gastrectomy at our hospital from 2000 to 2009 were analyzed retrospectively. They included three approaches of digestive tract reconstruction.

Silymarin enhanced cytotoxic effect of anti-Fas agonistic antibody CH11 on A375-S2 cells.

Silymarin is a polyphenolic flavonoid from milk thistle (Silybum marianum), which has anti-inflammatory, cytoprotective as well as antioxidant effects. Our previous study demonstrated that silymarin has anti-apoptotic effect against UV irradiation. In this study, we assessed the effect of silymarin on anti-Fas agonistic antibody CH11-treated human malignant melanoma, A375-S2 cells.

Two new thiophenes from Echinops latifolius and their phototoxic activities.

Two new thiophenes, 5-{4-[4-(5-pent-1,3-diynylthiophen-2-yl)-but-3-ynyloxy]-but-1-ynyl}-2,2'-bithiophene (1) and 5-(4-hydroxybut-1-one)-2,2'-bithiophene (2), together with two known thiophenes 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene (3) and 5-(3,4-dihydroxybut-1-ynyl)-2,2'-bithiophene (4), were isolated from the roots of Echinops latifolius Tausch. Their structures were elucidated based on the detailed NMR spectroscopic analysis and comparison with literature values. Compounds 1 and 2 showed significant inhibition activities against human cancer cell lines A375-S2 and HeLa with IC(50) values from 3.

Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1.

Terminally differentiated adult injured cardiac myocytes have been used for various animal models of heart failure. It has recently been shown that isoproterenol induces injury in rat neonatal cardiac myocytes via a beta-adrenergic pathway, suggesting that it might be one of the factors involved in myocardial cell injury in heart failure in vivo. In the study, silibinin, a plant flavanoid from milk thistle was first evaluated for its protective effect against beta-adrenergic agonist isoproterenol-induced injury in cultured rat neonatal cardiac myocytes.

Two new triterpenoids from the carpophore of Xanthoceras sorbifolia Bunge.

Two new triterpenoids 3-O-beta-d-glucopyranosyl (1-->6)-beta-d-glucopyranosyl, 28-O-beta-d-glucopyranosyl (1-->6) [alpha-l-rhamnopyranosyl (1-->2)]-beta-d-glucopyranosyl, 16-deoxybarringtogenol C (1) and 22-O-acetyl-21-O-(4'-O-angeloyl)-beta-d-fucopyranosyl theasapogenol B (2), were isolated from the dried carpophore of Xanthoceras sorbifolia Bunge (Sapindaceae). 1 and 2 were found to have activity of inhibiting the proliferation of two human tumor cell lines.

Sg17-1-4, a novel isocoumarin from a marine fungus Alternaria tenuis Sg17-1.

One novel isocoumarin, named Sg17-1-4, along with two known isocoumarins AI-77-B and AI-77-F were obtained from a marine fungus Alternaria tenuis Sg17-1. Their structures were elucidated based on detailed NMR analysis. The cytotoxicities of these compounds were evaluated in vitro.

Silibinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway.

Silymarin is a polyphenolic flavonoid from milk thistle (Silybum marianum), which has anti-inflammatory, cytoprotective, and anticarcinogenic effects. In this study, we assessed the effect of silibinin (Fig. 1), the major active compound in silymarin, on ultraviolet light (UV)-induced cell apoptosis in HaCaT cells, a human keratinocyte cell line.

The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis.

Silymarin is a polyphenolic flavonoid derived from milk thistle (Silybum marianum) and has anti-inflammatory, cytoprotective as well as anticarcinogenic effects [Manna, S.K., Mukhopadlhyay, A.

Two new triterpenes from the husks of Xanthoceras sorbifolia.

Two new triterpenes, 22-angeloyl-21-epoxyangeloylbarringtogenol C (1) and 21,22-diangeloyl-24-hydroxy-R(1)-barrigenol (2), and the known 21,22-diangeloyl-R(1)-barrigenol (3) were isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on detailed NMR analysis. Compounds 1 and 2 inhibited significantly the growth of cancer cell lines (A375-S2, HeLa) with IC(50) values ranging from 2.

Silymarin augments human cervical cancer HeLa cell apoptosis via P38/JNK MAPK pathways in serum-free medium.

Silymarin was proved to have a protective effect of UV-induced A375-S2 cell apoptosis in our previous research. In this study, its pro-apoptotic and anti-apoptotic activities on human cervical cancer (HeLa) cells in vitro were investigated. Silymarin induced HeLa cell death through both apoptotic and necrotic pathways.

Silymarin prevents UV irradiation-induced A375-S2 cell apoptosis.

Silymarin, a plant flavonoid from milk thistle (Silybum marianum [L.] GAERTNER) was first evaluated for its protective effect against UV irradiation-induced apoptosis in human malignant melanoma cells (A375-S2 cells). Treatment with silymarin 500 microM for 12 h significantly inhibited UV irradiation (2.

Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis.

Shikonin, isolated from the plant Lithospermum erythrorhizon Sieb. ET Zucc, inhibited tumor cell growth and induced cell death in various tumor cells, with 50% growth inhibition of human cervical cancer cells, HeLa, at 18.9 +/- 1.