Publications by authors named "Lin-Xiao Liao"
[Gene Mutation in Acute Lymphoblastic Leukemia by DNA Sequencing].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2020
Objective: To analyze the characteristics of gene mutation in adult ALL and its clinical significance.
Methods: Clinical data of 134 primary adult ALL patients and DNA sequencing results of 16 kinds of gene mutation were collected. The characteristic of gene mutation and clinical significances were statistically analyzed.
[NPM1 High Mutant Allele Burden is an Adverse Prognostic Factor for AML Patients with Mutated NPM1].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2019
Article Synopsis
- - The study focused on 73 adult patients with acute myeloid leukemia (AML) who have mutated NPM1, examining their clinical features, gene mutations, and prognostic factors.
- - Researchers detected 74 mutations in the NPM1 gene and found that different mutation sites did not significantly affect patient prognosis, but a higher variant allele frequency (VAF) was linked to worse early mortality and survival rates.
- - The presence of NRAS mutations correlated with better outcomes, including higher remission rates and prolonged overall survival, and NPM1 VAF greater than 38.4% emerged as a key independent predictor of worse prognosis in these patients.