Publications by authors named "Lin-Xiang Shi"
Article Synopsis
- The study investigates how estrogen receptor (ER) signaling contributes to acquired resistance against lapatinib in breast cancer cells.
- Researchers created a resistant cell model (rBT474) and examined the differences in signaling pathways between it and the original BT474 cells after treatment with lapatinib.
- The findings indicate that while lapatinib effectively inhibits HER2 signaling, the upregulation of ER pathways may allow resistant cells to survive, suggesting that combining lapatinib with an ER inhibitor like fulvestrant can enhance treatment efficacy.
The aim of this study was to investigate the antitumor effect of a plasmid co-expressing ENDO-VEGI151 and survivin siRNA on breast cancer in nude mice, and to explore the feasibility of attenuated Salmonella typhimurium (S. typhimurium) as a delivery vector for cancer gene therapy in vivo. Three recombinant expression plasmids pENDO‑VEGI151 (pEV), pSurvivin-siRNA (psi-survivin) and co-expressing plasmid pENDO-VEGI151/survivin‑siRNA (pEV/si-survivin), were transferred into the attenuated S.
View Article and Find Full Text PDFCABYR RNAi plasmid construction and NF-κB signal transduction pathway.
World J Gastroenterol
October 2010
Aim: To construct the CABYR RNAi plasmid and study its relation with the nuclear factor (NF)-κB signal transduction pathway.
Methods: Human CABYR mRNA sequence was obtained from GenBank. The structure of cDNA sequence for the short hairpin RNA was BbsI + sense + loop + antisense + transcription terminator + KpnI + BamHI.