Background: Video-assisted thoracoscopic surgery (VATS) has been widely used for the resection of lung lesions. However, it is difficult to palpate or see small lesions, especially ground-glass opacities (GGOs) during VATS. Thoracoscopic ultrasound has definite value in locating pulmonary parenchymal nodules.
View Article and Find Full Text PDFBackground: Much remains to be learned about patients with heart failure with improved ejection fraction (HFimpEF).
Objective: This study sheds light on the characteristics and clinical outcomes of HFimpEF patients, including the consequences of halting guideline-directed medical therapy (GDMT).
Methods: This retrospective study was conducted on patients diagnosed with heart failure with reduced ejection fraction (HFrEF) who underwent a second echocardiogram at least 6 months apart between January 2009 and February 2023.
Eur Heart J Cardiovasc Imaging
December 2024
Aims: Limited data exist on the natural history of functional mitral regurgitation (FMR), including atrial (AFMR), ventricular (VFMR), and dual FMR. This study examined the prevalence, characteristics, outcomes, and progression of these FMR subtypes.
Methods And Results: Consecutive patients with ≥mild to moderate FMR were included and classified as AFMR, VFMR, or dual FMR.
Background: Apical hypertrophic cardiomyopathy (ApHCM) is a variant of hypertrophic cardiomyopathy, with distinct clinical characteristics and outcomes. We aimed to clarify the natural history of patients with ApHCM and identify the risk of end-stage heart failure incidence.
Methods And Results: This retrospective study was conducted on patients with hypertrophic cardiomyopathy in China between January 2009 and February 2024.
There is insufficient data on systemic embolic events (SSEs) in patients with ischemic left ventricular aneurysm (LVA) concerning the impact of anticoagulation therapy. In this retrospective cohort study with 1043 patients with ischemic LVA, SSEs occurred in 7.2% over 2.
View Article and Find Full Text PDFIn recent years, hypertension has become one of the leading causes of illness and death worldwide. Changes in lifestyle among the population have led to an increasing prevalence of hypertension. This study proposes a non-contact blood pressure estimation method that allows patients to conveniently monitor their blood pressure values.
View Article and Find Full Text PDFBackground: The diagnosis and treatment of attention deficit hyperactivity disorder (ADHD) comorbid with epilepsy have been insufficiently addressed in China. We conducted a study in China to investigate the current status, diagnosis, and treatment of ADHD in children to further our understanding of ADHD comorbid with epilepsy, strengthen its management, and improve patients' quality of life.
Methods: We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August 2022.
Background: Obesity paradox has been reported in patients with cardiovascular disease, showing an inverse association between obesity as defined by BMI (in kg/m) and prognosis. Nutritional status is associated with systemic inflammatory response and affects cardiovascular disease outcomes.
Objectives: This study sought to examine the influence of obesity and malnutrition on the prognosis of patients with acute coronary syndrome (ACS).
Background: Whether heart failure with preserved ejection fraction (HFpEF) is associated with an increased risk of developing systolic dysfunction and a poor prognosis in hypertrophic cardiomyopathy (HCM) patients is unknown.
Objective: We aimed to assess risk factors for the development of end-stage (ES) heart failure (HF) (ejection fraction < 50%) and compare the prognosis of different HF phenotypes.
Methods: This retrospective study was conducted on patients with HCM in China between January 2009 and February 2023.
Since the outbreak of COVID-19, as of January 2023, there have been over 670 million cases and more than 6.8 million deaths worldwide. Infections can cause inflammation in the lungs and decrease blood oxygen levels, which can lead to breathing difficulties and endanger life.
View Article and Find Full Text PDFBiodegradable plastics have been widely used to replace conventional plastics to minimize environmental impacts of plastic packaging. However, before biodegradable plastics decompose in the environment, they could pose a threat to terrestrial and aquatic creatures by acting as vectors of contaminants in the food chain. In this study, conventional plastic bags (CPBs) made of polyethylene and biodegradable plastic bags (BPBs) made of polylactic acid were examined for their heavy metal adsorption.
View Article and Find Full Text PDFNeuroblastoma is the most common and deadliest tumor in infancy. WDR5 (WD Repeat Domain 5), a critical factor supporting an N-myc transcriptional complex via its WBM site and interacting with chromosome via its WIN site, promotes the progression of neuroblastoma, thus making it a potential anti-neuroblastoma drug target. So far, a few WIN site inhibitors have been reported, and the WBM site disruptors are rare to see.
View Article and Find Full Text PDFMicroplastics are frequently found in many environmental media. Polypropylene (PP) is one of the plastics commonly used, resulting in more and more PP fragments in natural waters. Contaminants, such as lead (Pb), could get adsorbed onto microplastics after the exposure to sunlight, and pose a larger threat to aquatic species.
View Article and Find Full Text PDFObjective: To observe the imaging features of focus of knee joint tendon in patients with knee osteoarthritis (KOA) by musculoskeletal ultrasound (MSUS) technique.
Methods: One hundred KOA patients and 100 healthy subjects were included. All the KOA patients were palpated by the sequence of foot meridian, foot meridian, foot meridian and foot three -meridians, and the focus of knee tendon and its frequency were recorded by MSUS technique.
Background: Wilson disease is a rare, disabling, neurological genetic disease. Biomarkers of brain damage are less well developed.
Objective: The aim of this study was to evaluate the utility of plasma glial fibrillary acidic protein as a biomarker for neurological involvement in patients with Wilson disease.
We report the design, synthesis, and biological evaluation of 13 new and 1 known anthraquinone derivatives which exerted cytotoxicity against PC3, A549 and NTUB1 cell lines. The results indicate that, among these 14, compounds-1 and 14 showed the highest growth inhibitory effect on NTUB1 and PC3 cells, respectively. Compound-1 at lower doses targets DNA, induces DNA damage and subsequently triggers G2/M arrest and apoptotic cell death at 24 h.
View Article and Find Full Text PDFBackground: The significance of () infection and atrophic gastritis (AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions.
Aim: To investigate whether infection, AG, and -related AG increase the risk of colorectal adenomas.
Ann Clin Transl Neurol
August 2020
Objective: Spinocerebellar ataxia type 3 (SCA3) is one of the most common hereditary neurodegenerative diseases, with balance instability as main symptom. Balance quantification is crucial for evaluating the efficacy of therapeutic interventions. However, balance evaluation in SCA3 is often subject to bias.
View Article and Find Full Text PDFPhys Chem Chem Phys
July 2019
Carbonyl oxides, also known as Criegee intermediates, are generated from ozonolysis of unsaturated hydrocarbons in the atmosphere. Alcohols are often used as a scavenger of the Criegee intermediates in laboratory studies. In this work, the reaction kinetics of CHCHOO with methanol vapor was investigated at various temperatures, pressures, and isotopic substitutions using time-resolved UV absorption spectroscopy.
View Article and Find Full Text PDFThe role of water in gas-phase reactions has gained considerable interest. Here we report a direct kinetic measurement of the reaction of syn-CHCHOO (a Criegee intermediate or carbonyl oxide) with methanol at various relative humidity (RH = 0-80%) under near-ambient conditions (298 K, 250-755 Torr). The data indicate that a single water molecule expedites the reaction by up to a factor of three.
View Article and Find Full Text PDFThis study investigated the characteristics and mechanisms of eravacycline resistance and heteroresistance in clinical Klebsiella pneumoniae isolates. A total of 393 clinical K. pneumoniae isolates were collected and subjected to eravacycline and tigecycline MIC determinations using the agar dilution method.
View Article and Find Full Text PDFThe autophagy of human prostate cancer cells (PC3 cells) induced by a new anthraquinone derivative, 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate (PA) was investigated, and the relationship between autophagy and reactive oxygen species (ROS) generation was studied. The results indicated that PA induced PC3 cell death in a time- and dose-dependent manner, could inhibit PC3 cell growth by G1 phase cell cycle arrest and corresponding decrease in the G2/M cell population and induced S-phase arrest accompanied by a significant decrease G2/M and G1 phase numbers after PC3 cells treated with PA for 48 h, and increased the accumulation of autophagolysosomes and microtubule-associated protein LC3-ll, a marker of autophagy. However, these phenomenon were not observed in the group pretreated with the autophagy inhibitor 3-MA or Bafilomycin A1 (BAF), suggesting that PA induced PC3 cell autophagy.
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