Publications by authors named "Lin-Rong Lu"
As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals. However, the underlying molecular basis for this remains elusive.
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- Rab5a is essential for muscle regeneration and is upregulated during myogenesis, indicating its critical role in skeletal muscle development.
- Rab5a promotes myoblast differentiation by interacting with insulin receptor substrate 1 (IRS1), particularly upon activation of IGF-1, and this interaction is crucial for effective signaling.
- The study reveals that Rab5a regulates the AKT-mTOR signaling pathway through its interaction with IRS1, highlighting its importance in coordinating muscle regeneration processes.
As tendon stem/progenitor cells were reported to be rare in tendon tissues, tendons as vulnerable targets of sports injury possess poor self-repair capability. Human ESCs (hESCs) represent a promising approach to tendon regeneration. But their teno-lineage differentiation strategy has yet to be defined.
View Article and Find Full Text PDFUbiquitin Conjugating Enzyme Ubc9 is Involved in Protein Degradation of Redox Factor-1 (Ref-1).
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
January 2000
Redox factor-1 (Ref-1) is a bifunctional protein playing an important role in both cellular redox regulation and DNA apurinic/apyrimidinic sites' repair. To find Ref-1interacting proteins (Rips), a yeast two-hybrid screening was performed by using Ref-1 redox domain as the 'bait', and five positive clones were obtained. One of them (Rip3) was identified to be the ubiquitin-conjugating enzyme Ubc9.
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