Publications by authors named "Lin-Qian Yang"
Article Synopsis
- Salivary adenoid cystic carcinoma (SACC) is a type of cancer that grows slowly but can spread to other parts of the body, especially the lungs, leading to serious health issues.
- Scientists studied a molecule called miR-103a-3p to see how it affects SACC and found that it is more active in cancer samples, helping the cancer cells move and spread.
- The researchers discovered that miR-103a-3p works by interacting with another protein called TPD52, and understanding this connection could help find new ways to treat or detect this type of cancer.
Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavorable outcome in patients with SACC. We found that upregulation of epiregulin in SACC cells induced epithelial-mesenchymal transition by regulating GLI1/E-cadherin.
View Article and Find Full Text PDFSalivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites.
View Article and Find Full Text PDFObjectives: Adenoid cystic carcinoma (ACC) is one of the most common malignancies of salivary glands, characterized by poor prognosis, particularly due to pulmonary metastasis. We previously reported that transforming growth factor (TGF)-β1 promoted ACC cell migration and invasion via the Smad pathway in vitro. The aim of this study was to establish the underlying mechanisms.
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