Compound mutations in the EGFR gene, particularly in lung adenocarcinoma, lead to poor responses to standard EGFR-tyrosine kinase inhibitors (TKIs).
A patient with a compound EGFR mutation (L858R/A871G) experienced rapid progression on erlotinib but responded well to icotinib, suggesting that different EGFR-TKIs may be effective depending on the specific mutation.
This case highlights the importance of recognizing diverse responses to various EGFR-TKIs and underscores the need for further research into how these mutations affect treatment outcomes.