Publications by authors named "Lin-Lin Zhang"

Purpose: To analyze the stress distribution of polyetheretherketone framework of implant-supported fixed maxillary prosthesis by three-dimensional finite element method.

Methods: Three dimensional finite element model of implant-supported fixed maxillary prosthesis was established. Polyetheretherketone as framework material, resin, zirconia, PEEK, baked plastic and lithium silicate were used to make crown prosthesis as experimental group, pure titanium and monolithic zirconia prosthesis model was used as control group.

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Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially, PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes.

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  • * Numerous pyridazine-based compounds have been created to inhibit processes linked to cancer, including blockers for GLS1, TRK, and BRD, which address tumor metabolism, signaling, and epigenetics.
  • * The review discusses the advancements made from 2020 to 2024 regarding pyridazine derivatives, emphasizing their structure-activity relationships and strategies for designing effective anticancer drugs.
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The objective of this study was to investigate the potential targets and mechanisms of UA in the treatment of PD. The efficacy of UA in PD was assessed through network pharmacology, molecular docking, and experimental methods. Common target protein-protein interaction (PPI) networks were constructed and visualized using Cytoscape.

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Purpose: To investigate the effects of erbium laser pretreatment on the bond strength of dentin and enamel,as well as microleakage at the edge of tooth defects repaired with computer-aided design (CAD) and computer-assisted manufacturing (CAM) glass-ceramic restorations for repairing dental defects.

Methods: A total of 62 fresh, nondecayed, nondiscoloration and noncracked wisdom teeth were collected from the Oral Surgery Clinic between January 2020 and January 2023. According to different pretreatment methods, they were randomly divided into two groups, erbium laser group and phosphoric acid group, with 31 teeth in each group.

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A facile, fast and visible sensing platform for ascorbic acid (AA) detection has been developed based on self-assembled hydrangea-like europium metal-organic framework (HL-EuMOF). HL-EuMOF was synthesized through a simple one-step mixing process with Eu and 1, 10-phenanthroline-2, 9-dicarboxylic acid at room temperature, which exhibited excellent properties including strong red fluorescence, long decay lifetime (548.623 μs) and good luminescent stability.

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Objective: To investigate the clinical effect of implant-assisted dental intentional replantation (IR) for the treatment of "drifted" anterior periodontally hopeless teeth (PHT).

Methods: The present authors recruited 22 patients with stage III/IV periodontitis who suffered drifting of the maxillary anterior teeth, with a total of 25 teeth. The PHT were extracted for in vitro root canal treatment (RCT).

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Objective: To investigate the effect of CD8 CD28 T cells on acute graft-versus-host disease(aGVHD) after haploidentical hematopoietic stem cell transplantation(haplo-HSCT).

Methods: The relationship between absolute count of CD8 CD28 T cells and aGVHD in 60 patients with malignant hematological diseases was retrospectively analyzed after haplo-HSCT, and the differences in the incidence rate of chronic graft-versus host disease(cGVHD), infection and prognosis between different CD8 CD28 T absolute cells count groups were compared.

Results: aGVHD occurred in 40 of 60 patients after haplo-HSCT, with an incidence rate of 66.

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Heat shock transcription factors (HSFs) play a crucial role in heat stress tolerance in vegetative tissues. However, their involvement in reproductive tissues and their post-translational modifications are not well understood. In this study, we identify the E3 ligase XB3 ORTHOLOG 1 IN ARABIDOPSIS THALIANA (XBAT31) as a key player in the ubiquitination and degradation of HSFB2a/B2b.

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  • Biomarkers require detailed analysis at the single-molecule level for accurate clinical diagnosis, leading to the use of highly sensitive biological nanopore technology for detection.
  • The development of a droplet nanopore technique allows for low-volume and high-throughput detection of biomarkers, achieving a 2000-fold reduction in sample volume compared to traditional methods.
  • This new sensing platform successfully lowers detection limits to 42 picograms for biomarkers like angiotensin II, making it a strong candidate for point-of-care testing without excessive sample dilution.
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  • The study aimed to systematically review the effectiveness of combining transcatheter arterial chemoembolization (TACE) with portal vein embolization (PVE) for treating hepatocellular carcinoma (HCC).
  • A comprehensive search of various databases identified eight eligible studies involving 689 patients, comparing TACE plus PVE to PVE alone.
  • Findings indicated that the combination treatment led to a higher future liver remnant and improved outcomes, such as greater disease-free survival and fewer complications, with no significant impact on mortality rates.
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Endometrial elasticity is a potential new marker for assessing endometrial receptivity and pregnancy outcomes based on endometrial thickness and type. Currently, little research has been conducted on the elasticity of the endometrium using shear wave elasticity imaging (SWEI). This study aimed to explore whether endometrial elasticity is an ultrasound marker for predicting clinical pregnancy outcomes after embryo transfer.

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  • Myopia is a common eye condition linked to lifestyle factors, and this study evaluates how leisure activities, physical activity, and sleep patterns contribute to its development.
  • Using genetic data from large databases, researchers applied Mendelian randomization to analyze the causal effects of these behaviors on myopia.
  • Findings suggest that increased computer use raises myopia risk, while moderate-to-vigorous physical activity and television watching may help reduce the risk.
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Background: Lanthanide metal-organic frameworks (Ln-MOFs) are a kind of emerging crystalline porous materials with high fluorescence and easy-to-tunable properties, making them ideal for sensing applications. However, current Ln-MOFs based fluorescent probes are primarily single-emissive or fluorescence-quenched, which greatly limited the detection performances such as sensitivity, accuracy and repeatability, thereby hindering their applications in efficient target monitoring and related disease diagnosis. To address these issues, the reasonable design of Ln-MOFs equipped with dual fluorescence emissions and light-up mode is urgently needed for a high-performance biosensor.

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Plants are highly susceptible to abiotic stresses, particularly heat stress during the reproductive stage. However, the specific molecular mechanisms underlying this sensitivity remain largely unknown. In the current study, we demonstrate that the Nuclear Transcription Factor, X-box Binding Protein 1-Like 1 (NFXL1), directly regulates the expression of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2A (DREB2A), which is crucial for reproductive thermotolerance in Arabidopsis.

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Background: Autistic traits (ATs) are frequently reported in children with Attention-Deficit/Hyperactivity Disorder (ADHD). This study aimed to examine ATs in children with ADHD from both behavioral and neuroimaging perspectives.

Methods: We used the Autism Spectrum Screening Questionnaire (ASSQ) to assess and define subjects with and without ATs.

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  • Ledeb. is a perennial herb from the Compositae family, grown in China for its medicinal, ornamental, and edible uses, and was affected by a leaf spot disease in 2021, with over 37% of plants showing symptoms.
  • Infected leaves exhibited irregular reddish-brown spots that progressed to withering and merging into larger lesions, though roots and stems were unaffected during the reproductive stage.
  • Research involved isolating the pathogen from diseased leaves and identifying it through morphological characteristics and genetic analysis, eventually confirming the identity of isolate TYTW7 based on established methods.
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  • Maxim. ex Oliv. is a perennial medicinal plant cultivated in China, but it suffers significant production losses due to anthracnose disease, which affected over 40% of plants in a sampled field in 2021.
  • * The symptoms of anthracnose include black spots on leaves, primarily at the edges, leading to leaf wilting and drop while younger leaves are usually unaffected.
  • * Fungal isolates were collected from symptomatic leaves, and one isolate, SQZ9, was identified through morphological features and genetic sequencing, revealing similarities to other known fungal species.
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Objective: To investigate the clinical features of transplant-associated thrombotic microangiopathy (TA-TMA) and the prognostic value of different prognostic risk models for TA-TMA.

Methods: The clinical characteristics of 32 TA-TMA patients diagnosed at the First Medical Center of the PLA General Hospital from January 2018 to February 2022 in terms of short-term prognosis and influencing factors were retrospectively analyzed. In addition, the risk population composition ratio, treatment response, and overall survival between the BATAP risk model and the TMA index model were compared, as well as the efficacy of two prognostic risk models for predicting death in patients with TA-TMA.

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Background: The enhanced recovery after surgery (ERAS) program helps patients recover faster and better, postoperatively. The aim of this retrospective study was to assess the clinical effectiveness of the ERAS program after percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures.

Methods: We enrolled patients with osteoporotic vertebral compression fracture who had undergone PKP between January 2019 and June 2021 and divided them into the control group (CG; n = 296), without the ERAS program, and the intervention group (IG; n = 306), with the ERAS program.

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  • Anti-PD-1 monotherapy was found to be ineffective for patients with relapsed/refractory AML showing high levels of PD-1 and PD-L1, leading to a study of a combination therapy involving PD-1 inhibitors and hypomethylating agents.
  • In a phase 2 trial with 27 patients, the combination therapy achieved a 63% objective response rate, with median overall survival not reached in responders and median event-free survival at 9.2 months.
  • The combination of tislelizumab, hypomethylating agents, and the CAG regimen showed promising results with mild adverse effects, while higher levels of specific T cells may indicate better treatment outcomes.
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Xanthates with different alkyl groups, such as ethyl, propyl, butyl, and amyl groups, are widely used in large quantities in the mining flotation of metallic minerals. Xanthates enter environmental waters through mineral processing wastewater discharge and are ionized or hydrolyzed into ions or molecules of xanthic acids (XAs) in water. XAs endanger aquatic plants and animals, as well as human health.

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