Increased circulating erythrocyte-derived microparticles in patients with acute coronary syndromes.

This study is to explore the predictive value of erythrocyte-derived microparticles (ErMPs) in patients with acute coronary syndrome (ACS). Total 305 subjects were enrolled and divided into the control group and ACS group. Flow cytometry was used to detect the ErMPs.

PTP1B Inhibitors from the Entomogenous Fungi Isaria fumosorosea.

Protein tyrosine phosphatase 1B (PTP1B) is implicated as a negative regulator of insulin receptor (IR) signaling and a potential drug target for the treatment of type II diabetes and other associated metabolic syndromes. Thus, small molecule inhibitors of PTP1B can be considered as an attractive approach for the design of new therapeutic agents of type II diabetes and cancer diseases. In a continuing search for new PTP1B inhibitors, a new tetramic acid possessing a rare pyrrolidinedione skeleton named fumosorinone A (), together with five known ones - were isolated from the entomogenous fungus The structures of - were elucidated by extensive spectroscopic analysis.