[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms].

Objective: To investigate the significance and mechanisms of overexpression of p21-activated kinase 1 gene (PAK1) in epithelial ovarian neoplasms.

Methods: Immunohistochemistry, fluorescence in situ hybridization and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling methods were used to examine the protein expression and amplification of PAK1 and cell apoptosis in 30 benign ovarian adenomas, 20 borderline tumors and 80 ovarian carcinomas by tissue microarray.

Results: In immunohistochemistry study, overexpression of PAK1 protein was observed in 7 (25.